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Literature summary for 2.7.1.76 extracted from
- Inhibition of deoxynucleoside kinases in human thymocytes prevents dATP accumulation and induction of apoptosis (2008), Nucleosides Nucleotides Nucleic Acids, 27, 816-820.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | thymocytes lacking adenosine deaminase activity accumulate intracellular dATP and undergo apoptosis. Inhibition of both deoxycytidine kinase and adenosine kinase completely abrogates accumulation of dATP and significantly reduces the induction of apoptosis | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5'-amino-5'-deoxyadenosine | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| thymocyte | suspension culture | Homo sapiens | - |
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