Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.71 extracted from

  • Rosado, L.A.; Vasconcelos, I.B.; Palma, M.S.; Frappier, V.; Najmanovich, R.J.; Santos, D.S.; Basso, L.A.
    The mode of action of recombinant Mycobacterium tuberculosis shikimate kinase: kinetics and thermodynamics analyses (2013), PLoS ONE, 8, e61918.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.112
-
ATP at pH 7.6 and 25°C Mycobacterium tuberculosis
0.65
-
shikimate at pH 7.6 and 25°C Mycobacterium tuberculosis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mycobacterium tuberculosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
18451
-
-
Mycobacterium tuberculosis
20700
-
gel filtration Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + shikimate Mycobacterium tuberculosis
-
ADP + 3-phosphoshikimate
-
r

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
phenyl Sepharose column chromatography and Sephacryl S-100 gel filtration Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + shikimate
-
Mycobacterium tuberculosis ADP + 3-phosphoshikimate
-
r

Subunits

Subunits Comment Organism
monomer 1 * 18451, calculated from amino acid sequence Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
AroL
-
Mycobacterium tuberculosis
type II shikimate kinase
-
Mycobacterium tuberculosis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
60
-
ATP at pH 7.6 and 25°C Mycobacterium tuberculosis
60
-
shikimate at pH 7.6 and 25°C Mycobacterium tuberculosis

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
54
-
ATP at pH 7.6 and 25°C Mycobacterium tuberculosis
90
-
shikimate at pH 7.6 and 25°C Mycobacterium tuberculosis