Application | Comment | Organism |
---|---|---|
drug development | the enzyme is an attractive drug target | Shigella flexneri |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme structure analysis and modeling for rational drug designing, overview | Shigella flexneri |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Shigella flexneri |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + shikimate | Shigella flexneri | - |
ADP + 3-phosphoshikimate | - |
? | |
ATP + shikimate | Shigella flexneri 8401 | - |
ADP + 3-phosphoshikimate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Shigella flexneri | - |
serotype 5b | - |
Shigella flexneri 8401 | - |
serotype 5b | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + shikimate | - |
Shigella flexneri | ADP + 3-phosphoshikimate | - |
? | |
ATP + shikimate | - |
Shigella flexneri 8401 | ADP + 3-phosphoshikimate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 26973.6, sequence calculation | Shigella flexneri |
More | prediction of enzyme secondary sstructure, overview | Shigella flexneri |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Shigella flexneri |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Shigella flexneri | sequence calculation | - |
5.61 |
General Information | Comment | Organism |
---|---|---|
additional information | comparative modeling approach, molecular dynamics calculations using the Escherichia coli structure as template, prediction of in silico and disordered regions, enzyme structure analysis and modeling, overview | Shigella flexneri |