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Literature summary for 2.7.1.68 extracted from

  • Nelson, C.D.; Kovacs, J.J.; Nobles, K.N.; Whalen, E.J.; Lefkowitz, R.J.
    Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor (2008), J. Biol. Chem., 283, 21093-21101.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-203 cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information chimeric protein in which the core kinase domain of phosphatidylinositol 4-phosphate 5-kinase 1alpha has been fused to a beta-arrestin mutant deficient in phosphatidylinositol 4,5-bisphosphate binding rescues internalization of beta2-adrenergic receptor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens beta-arrestins direct the localization of phosphatidylinositol 4-phosphate 5-kinase 1alpha and phosphatidylinositol 4,5-bisphosphate production to agonist-activated 7-transmembrane receptors, thereby regulating receptor internalization ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information beta-arrestins direct the localization of phosphatidylinositol 4-phosphate 5-kinase 1alpha and phosphatidylinositol 4,5-bisphosphate production to agonist-activated 7-transmembrane receptors, thereby regulating receptor internalization Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More following stimulation of the beta2-adrenergic receptor, beta-arrestins bind phosphatidylinositol 4-phosphate 5-kinase 1alpha. A beta-arrestin mutant deficient in phosphatidylinositol 4,5-bisphosphate binding fails to interact with phosphatidylinositol 4-phosphate 5-kinase 1alpha and is not associated with phosphatidylinositol kinase activity in vitro, and no longer internalizes beta2-adrenergic receptor Homo sapiens