Literature summary for 2.7.1.68 extracted from

Weixel, K.M.; Edinger, R.S.; Kester, L.; Guerriero, C.J.; Wang, H.; Fang, L.; Kleyman, T.R.; Welling, P.A.; Weisz, O.A.; Johnson, J.P.
Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells (2007), J. Biol. Chem., 282, 36534-36542.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Xenopus laevis oocyte	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
D203A	catalytically inactive. Expression in Xenopus laevis oocyte has no effect on epithelial sodium channel activity	Mus musculus
D227A	catalytically inactive. Expression in Xenopus laevis oocyte has no effect on epithelial sodium channel activity	Mus musculus
additional information	expression of phosphatidylinositol 4-phosphate 5-kinase alpha in Xenopus laevis oocytes decreases epithelial sodium channel currents by 80%, entirely due to a decrease in cell surface epithelial sodium channel levels. Expression of catalytically inactive mutants has no effect on epithelial sodium channel activity. Knock-down of phosphatidylinositol 4-phosphate 5-kinase alpha with isoform-specific siRNA results in a 4fold enhancement of epithelial sodium channel activity	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	upon overexpression in CCD cells, enzyme localizes exclusively in apical plasma membrane	Mus musculus	5886	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	isoform phosphatidylinositol 4-phosphate 5-kinase alpha	-

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Release 2023.1 (January 2023)