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Literature summary for 2.7.1.68 extracted from

  • Weinkove, D.; Bastiani, M.; Chessa, T.A.; Joshi, D.; Hauth, L.; Cooke, F.T.; Divecha, N.; Schuske, K.
    Overexpression of PPK-1, the Caenorhabditis elegans type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults (2008), Dev. Biol., 313, 384-397.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
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 Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
additional information overexpression of isoform PPK-1 in Caenorhabditis elegans causes an increase in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels in vivo. In developing neurons, PPK-1 overexpression leads to growth cones that become stalled, produce ectopic membrane projections, and branched axons. Once neurons are established, PPK-1 overexpression results in progressive membrane overgrowth and degeneration during adulthood Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane enzyme can localize to the plasma membrane Caenorhabditis elegans 5886
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Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans O01759 isoform Ppk-1, type I enzyme
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Source Tissue

Source Tissue Comment Organism Textmining
nervous system strong expression Caenorhabditis elegans
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
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 Caenorhabditis elegans ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
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 ?