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Literature summary for 2.7.1.68 extracted from

  • Bazenet, C.E.; Anderson, R.A.
    Phosphatidylinositol-4-phosphate 5-kinases from human erythrocytes (1992), Methods Enzymol., 209, 189-202.
    View publication on PubMed
Search for more literature for 2.7.1.68

Activating Compound

Activating Compound Comment Organism Structure
heparin type I enzyme is stimulated at low concentrations Homo sapiens
spermine 2 mM, 4fold increase in activity of type I enzyme, no effect on type II enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
heparin type II kinase Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0012
-
 1-phosphatidyl-1D-myo-inositol 4-phosphate in 1-phosphatidyl-1D-myo-inositol 4-phosphate in membranes, type I enzyme Homo sapiens
0.0014
-
 1-phosphatidyl-1D-myo-inositol 4-phosphate in 1-phosphatidyl-1D-myo-inositol 4-phosphate liposomes, type I enzyme Homo sapiens
0.005
-
 ATP type II enzyme Homo sapiens
0.006
-
 1-phosphatidyl-1D-myo-inositol 4-phosphate in 1-phosphatidyl-1D-myo-inositol 4-phosphate micelles, type I enzyme Homo sapiens
0.025
-
 ATP type I enzyme Homo sapiens
0.04
-
 1-phosphatidyl-1D-myo-inositol 4-phosphate in 1-phosphatidyl-1D-myo-inositol 4-phosphate liposomes, type II enzyme Homo sapiens
0.06
-
 1-phosphatidyl-1D-myo-inositol 4-phosphate in 1-phosphatidyl-1D-myo-inositol 4-phosphate micelles, type II enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol type I kinase is membrane bound and type II kinase is both membrane bound and cytosolic Homo sapiens 5829
-
membrane type I kinase is membrane bound and type II kinase is both membrane bound and cytosolic Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53000
-
 x * 53000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
cytosolic enzyme type II enzyme and membrane-bound type I and type II enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte two form of PIP kinase: type I kinase is membrane bound and type II kinase is both membrane bound and cytosolic Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.015
-
 membrane bound type II enzyme Homo sapiens
0.023
-
 cytosolic enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
GTP + 1-phosphatidyl-1D-myo-inositol 4-phosphate 0.05 mM GTP is 2fold more active than ATP with type II enzyme. 0.05 mM GTP is 5fold more active than ATP with the type I enzyme Homo sapiens GDP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 53000, SDS-PAGE Homo sapiens