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Literature summary for 2.7.1.59 extracted from

  • Yamada-Okabe, T.; Sakamori, Y.; Mio, T.; Yamada-Okabe, H.
    Identification and characterization of the genes for N-acetylglucosamine kinase and N-acetylglucosamine-phosphate deacetylase in the pathogenic fungus Candida albicans (2001), Eur. J. Biochem., 268, 2498-2505.
    View publication on PubMed
Search for more literature for 2.7.1.59

Cloned(Commentary)

Cloned (Comment) Organism
functionally expressed in Escherichia coli as glutathione-S-transferase fusion protein, active enzyme Homo sapiens
functionally expressed in Escherichia coli as glutathione-S-transferase fusion protein, active enzyme Candida albicans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.376
-
 N-acetyl-D-glucosamine 37°C, pH 7.5 Candida albicans
0.426
-
 D-mannose 37°C, pH 7.5 Candida albicans
0.445
-
 N-acetyl-D-glucosamine 37°C, pH 7.5 Homo sapiens
0.483
-
 D-glucose 37°C, pH 7.5 Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + N-acetyl-D-glucosamine Homo sapiens
-
 ADP + N-acetyl-D-glucosamine 6-phosphate
-
 ?
ATP + N-acetyl-D-glucosamine Candida albicans first reaction of inducible N-acetylglucosamine catabolic pathway, enables organism to grow on N-acetylglucosamine as sole carbon source ADP + N-acetyl-D-glucosamine 6-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
fusion protein from Escherichia coli Homo sapiens
fusion protein from Escherichia coli Candida albicans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-glucose
-
 Candida albicans ADP + D-glucose 6-phosphate
-
 ?
ATP + D-mannose
-
 Candida albicans ?
-
 ?
ATP + N-acetyl-D-glucosamine
-
 Homo sapiens ADP + N-acetyl-D-glucosamine 6-phosphate
-
 ?
ATP + N-acetyl-D-glucosamine
-
 Candida albicans ADP + N-acetyl-D-glucosamine 6-phosphate
-
 ?
ATP + N-acetyl-D-glucosamine first reaction of inducible N-acetylglucosamine catabolic pathway, enables organism to grow on N-acetylglucosamine as sole carbon source Candida albicans ADP + N-acetyl-D-glucosamine 6-phosphate
-
 ?
additional information D-fructose, D-galactose, galactosamine, N-acetyl-D-galactosamine, mannosamine, N-acetyl-D-mannosamine do not serve as substrates Homo sapiens ?
-
 ?
additional information D-fructose, D-galactose, galactosamine, N-acetyl-D-galactosamine, mannosamine, N-acetyl-D-mannosamine do not serve as substrates Candida albicans ?
-
 ?

Synonyms

Synonyms Comment Organism
CaNag5p part of cluster with 6 genes, product from gene CaNag5 Candida albicans
CaNag5p
-
 Candida albicans

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.03
-
 N-acetyl-D-glucosamine 37°C, pH 7.5 Candida albicans
0.0325
-
 N-acetyl-D-glucosamine 37°C, pH 7.5 Homo sapiens