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Literature summary for 2.7.1.40 extracted from

  • Gruening, N.M.; Rinnerthaler, M.; Bluemlein, K.; Muelleder, M.; Wamelink, M.M.; Lehrach, H.; Jakobs, C.; Breitenbach, M.; Ralser, M.
    Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells (2011), Cell Metab., 14, 415-427.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.40

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pyruvate Saccharomyces cerevisiae
-
 ADP + phosphoenolpyruvate
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate
-
 Saccharomyces cerevisiae ADP + phosphoenolpyruvate
-
 ?

Synonyms

Synonyms Comment Organism
PYK
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells. Low PYK activity activates yeast respiration, the central metabolism is self-adapting to synchronize redox metabolism when respiration is activated. A metabolic feedback loop is responsible for preventing an increase in reactive oxygen species upon respiration activation. Low PYK enzyme activity causes accumulation of phosphoenolpyruvate, which in turn inhibits triose phosphate isomerase, an enzyme of upper glycolysis. This inhibition of triose phosphate isomerase increases metabolite content of the pentose phosphate pathway, a catabolic pathway closely connected to glycolysis. The PYK-PEP-TPI feedback loop protects cells from ROS-induced damage during respiration, metabolic mechanism, overview Saccharomyces cerevisiae