Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | alanine is a nonallosteric analogue of phenylalanine, it binds competitively with phenylalanine but elicits a negligible allosteric inhibition, i.e., a negligible reduction in the affinity of the muscle enzyme for the substrate, phosphoenolpyruvate | Oryctolagus cuniculus | |
phenylalanine | allosteric inhibitor, regions of pyruvate kinase important for allosteric regulation by phenylalanine, H/D exchange mass spectrometry, overview | Oryctolagus cuniculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | binds at the active site | Oryctolagus cuniculus | |
Mn2+ | required, binds at the active site | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate | Oryctolagus cuniculus | - |
ADP + phosphoenolpyruvate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
muscle | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate | - |
Oryctolagus cuniculus | ADP + phosphoenolpyruvate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | crystal structure | Oryctolagus cuniculus |
Synonyms | Comment | Organism |
---|---|---|
rM1-PYK | - |
Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Oryctolagus cuniculus |
General Information | Comment | Organism |
---|---|---|
additional information | allosteric mechanism of rM1-PYK, overview | Oryctolagus cuniculus |