Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | isoform pyruvate kinase M2 | Homo sapiens | - |
HEK-293T cell | isoform pyruvate kinase M2 | Homo sapiens | - |
HeLa cell | isoform pyruvate kinase M2 | Homo sapiens | - |
MCF-10A cell | isoform pyruvate kinase M2 | Homo sapiens | - |
muscle | isoform pyruvate kinase M1 | Homo sapiens | - |
NCI-H1299 cell | isoform pyruvate kinase M2 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphoenolpyruvate | - |
Homo sapiens | ATP + pyruvate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKM1 | splice isoform of pyruvate kinase | Homo sapiens |
PKM2 | splice isoform of pyruvate kinase | Homo sapiens |
pyruvate kinase M1 | splice isoform of pyruvate kinase | Homo sapiens |
pyruvate kinase M2 | splice isoform of pyruvate kinase | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | PKM1 expression reduces the tumorigenicity of lung cancer cells, the M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth, the switch to the M2 isoform of pyruvate kinase in tumour cells is necessary to cause the metabolic phenotype known as the Warburg effect, PKM2 knockdown is rescued by expression of PKM1 in vitro | Homo sapiens |