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Literature summary for 2.7.1.40 extracted from

  • Christofk, H.R.; Vander Heiden, M.G.; Harris, M.H.; Ramanathan, A.; Gerszten, R.E.; Wei, R.; Fleming, M.D.; Schreiber, S.L.; Cantley, L.C.
    The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth (2008), Nature, 452, 230-233.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell isoform pyruvate kinase M2 Homo sapiens
-
HEK-293T cell isoform pyruvate kinase M2 Homo sapiens
-
HeLa cell isoform pyruvate kinase M2 Homo sapiens
-
MCF-10A cell isoform pyruvate kinase M2 Homo sapiens
-
muscle isoform pyruvate kinase M1 Homo sapiens
-
NCI-H1299 cell isoform pyruvate kinase M2 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphoenolpyruvate
-
Homo sapiens ATP + pyruvate
-
?

Synonyms

Synonyms Comment Organism
PKM1 splice isoform of pyruvate kinase Homo sapiens
PKM2 splice isoform of pyruvate kinase Homo sapiens
pyruvate kinase M1 splice isoform of pyruvate kinase Homo sapiens
pyruvate kinase M2 splice isoform of pyruvate kinase Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ADP
-
Homo sapiens

General Information

General Information Comment Organism
physiological function PKM1 expression reduces the tumorigenicity of lung cancer cells, the M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth, the switch to the M2 isoform of pyruvate kinase in tumour cells is necessary to cause the metabolic phenotype known as the Warburg effect, PKM2 knockdown is rescued by expression of PKM1 in vitro Homo sapiens