Literature summary for 2.7.1.40 extracted from

Ameho, C.K.; Chen, C.Y.; Smith, D.; Sanchez-Moreno, C.; Milbury, P.E.; Blumberg, J.B.
Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats (2008), J. Nutr. Biochem., 19, 467-474.

Application

Application	Comment	Organism
medicine	vitamin E-deficient diets decrease serum alpha-tocopherol and increase pyruvate kinase activity in a time-dependent manner. The vitamin E-deficient diet increases plasma protein carbonyls but does not affect malondialdehyde. Dietary quercetin supplementation increases quercetin and its metabolites in plasma and liver but does not affect vitamin E deficiency-induced changes in plasma alpha-tocopherol, pyruvate kinase or protein carbonyls. Plasma isorhamnetin and its disposition in muscle are enhanced by the vitamin E deficient diet, as compared to the vitamin E-replete diet. Tamarixetin disposition in muscle is decreased by the vitamin E-deficient diet	Rattus norvegicus
nutrition	vitamin E-deficient diets decrease serum alpha-tocopherol and increase pyruvate kinase activity in a time-dependent manner. The vitamin E-deficient diet increases plasma protein carbonyls but does not affect malondialdehyde. Dietary quercetin supplementation increases quercetin and its metabolites in plasma and liver but does not affect vitamin E deficiency-induced changes in plasma alpha-tocopherol, pyruvate kinase or protein carbonyls. Plasma isorhamnetin and its disposition in muscle are enhanced by the vitamin E deficient diet, as compared to the vitamin E-replete diet. Tamarixetin disposition in muscle is decreased by the vitamin E-deficient diet	Rattus norvegicus

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	fed with vitamin E-replete and -defcient diet	-