Literature summary for 2.7.1.40 extracted from

Ogasawara, Y.; Funakoshi, M.; Ishii, K.
Pyruvate kinase is protected by glutathione-dependent redox balance in human red blood cells exposed to reactive oxygen species (2008), Biol. Pharm. Bull., 31, 1875-1881.

Search for more literature for 2.7.1.40

Inhibitors

Inhibitors	Comment	Organism	Structure
hydroxyl radical	inactivation	Homo sapiens
additional information	hydrogen peroxide does not inactivate	Homo sapiens
t-butyl hydroperoxide	in hemolysate exposed to t-butyl hydroperoxide, pyruvate kinase activity decreases along with depletion of glutathione. The addition of glutathione, but not glucose, before exposure completely prevents the inactivation of pyruvate kinase, partial reactivation of inactivated pyruvate kinase is observed by post-addition of both glutathione and glutaredoxin	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Renatured (Commentary)

Renatured (Comment)	Organism
in hemolysate exposed to t-butyl hydroperoxide, pyruvate kinase activity decreases along with depletion of gluathione. The addition of glutathione, but not glucose, before exposure completely prevents the inactivation of pyruvate kinase, partial reactivation of inactivated pyruvate kinase is observed by post-addition of both glutathione and glutaredoxin	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-

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Release 2023.1 (January 2023)