Literature summary for 2.7.1.40 extracted from

Iori, E.; Millioni, R.; Puricelli, L.; Arrigoni, G.; Lenzini, L.; Trevisan, R.; James, P.; Rossi, G.P.; Pinna, L.A.; Tessari, P.
Glycolytic enzyme expression and pyruvate kinase activity in cultured fibroblasts from type 1 diabetic patients with and without nephropathy (2008), Biochim. Biophys. Acta, 1782, 627-633.

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Application

Application	Comment	Organism
medicine	type 1 diabetic patients with nephropathy show increases in the gene expression of hexokinase, phosphoglucomutase, phosphofructokinase, aldolase and triosephosphate isomerase and alterations in protein levels of pyruvate kinase, triosephosphate isomerase, and enolase. Pyruvate kinase activity in fibroblasts from type 1 diabetic patients with nephropathy is lower than in type 1 diabetic patients without nephropathy and in controls	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14618	type 1 diabetic patients with and without nephropathy	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	vultured skin fibroblast	Homo sapiens	-

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Release 2023.1 (January 2023)