Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 cells | Trypanosoma cruzi |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
glycosome | - |
Trypanosoma cruzi | 20015 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
34000 | - |
2 * 34000, SDS-PAGE | Trypanosoma cruzi |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-mevalonate | Trypanosoma cruzi | - |
ADP + (R)-5-phosphomevalonate | - |
? | |
ATP + (R)-mevalonate | Trypanosoma cruzi CL Brener | - |
ADP + (R)-5-phosphomevalonate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | Q4CLD0 | - |
- |
Trypanosoma cruzi CL Brener | Q4CLD0 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography and Superdex 200 gel filtration | Trypanosoma cruzi |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
72.8 | - |
at pH 7.2 and 37°C | Trypanosoma cruzi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-mevalonate | - |
Trypanosoma cruzi | ADP + (R)-5-phosphomevalonate | - |
? | |
ATP + (R)-mevalonate | - |
Trypanosoma cruzi CL Brener | ADP + (R)-5-phosphomevalonate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 34000, SDS-PAGE | Trypanosoma cruzi |
Synonyms | Comment | Organism |
---|---|---|
MVK | - |
Trypanosoma cruzi |
General Information | Comment | Organism |
---|---|---|
physiological function | thebifunctional enzyme, in addition to playing a classical role in isoprenoid synthesis in lycosomes, it is secreted and modulates host cell signaling required for Trypanosoma cruzi invasion | Trypanosoma cruzi |