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Literature summary for 2.7.1.36 extracted from

  • Rios, S.E.; Cho, Y.K.; Miziorko, H.M.
    Characterization of mevalonate kinase V377I, a mutant implicated in defective isoprenoid biosynthesis and HIDS/periodic fever syndrome (2001), Biochim. Biophys. Acta, 1531, 165-168.
    View publication on PubMed
Search for more literature for 2.7.1.36

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.024
-
 (R,S)mevalonate
-
 Homo sapiens
0.074
-
 ATP
-
 Homo sapiens
0.1
-
 ATP V377I mutant mevalonate kinase Homo sapiens
0.167
-
 (R,S)mevalonate V377I mutant mevalonate kinase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + mevalonate
-
 Homo sapiens ADP + phosphomevalonate
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
 rate constant for inactivation of wild-type and V377I mevalonate kinase: 0.026 and 0.031/min Homo sapiens