Any feedback?
Literature summary for 2.7.1.36 extracted from
- Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways (1997), J. Lipid Res., 38, 2216-2223.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3,3-dimethylallyl diphosphate | - |
Homo sapiens |  |
| dolichol phosphate | - |
Homo sapiens | |
| farnesol | - |
Homo sapiens | |
| farnesyl diphosphate | - |
Homo sapiens | |
| geranyl diphosphate | - |
Homo sapiens | |
| geranylgeranyl diphosphate | - |
Homo sapiens | |
| isopentenyl diphosphate | - |
Homo sapiens | |
| additional information | not inhibited by R-mevalonate 5-diphosphate, geraniol and dolichol up to 0.084, 0.226 and 0.68 mM, respectively | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.15 | - |
(R,S)-mevalonate | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
| 0.44 | - |
ATP | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 42500 | - |
x * 42500, recombinant mevalonate kinase, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + mevalonate | Homo sapiens | part of the cholesterol and nonsterol isoprene biosynthetic pathway | ADP + phosphomevalonate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant mevalonat kinase-glutathione S-transferase fusion protein, glutathione Sepharose beads | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + mevalonate | - |
Homo sapiens | ADP + phosphomevalonate | - |
? | |
| ATP + mevalonate | part of the cholesterol and nonsterol isoprene biosynthetic pathway | Homo sapiens | ADP + phosphomevalonate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 42500, recombinant mevalonate kinase, SDS-PAGE | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000104 | - |
farnesyl diphosphate | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
| 0.016 | - |
isopentenyl diphosphate | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
| 0.02 | - |
3,3-dimethylallyl diphosphate | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
| 0.059 | - |
geranylgeranyl diphosphate | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
| 0.072 | - |
farnesol | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
| 0.083 | - |
dolichol phosphate | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
| 0.116 | - |
geranyl diphosphate | pH 7.0, 25°C, recombinant mevalonate kinase | Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
