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Literature summary for 2.7.1.36 extracted from

  • Williamson, I.P.; Kekwick, R.G.O.
    The formation of 5-phosphomevalonate by mevalonate kinase in Hevea brasiliensis latex (1965), Biochem. J., 96, 862-871.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
cysteine not required for activity Hevea brasiliensis

Inhibitors

Inhibitors Comment Organism Structure
CuSO4 0.1 mM, 56% inhibition, 1 mM, 77% inhibition Hevea brasiliensis
EDTA
-
Hevea brasiliensis
HgCl2 0.1 mM, 90% inhibition Hevea brasiliensis
additional information not inhibited by iodoacetamide Hevea brasiliensis
N-ethylmaleimide 0.1 mM, 66% inhibition, 1 mM, 94% inhibition Hevea brasiliensis
p-chloromercuribenzoate 0.1 mM, 95% inhibition, 1 mM, complete inhibition Hevea brasiliensis
ZnSO4 0.1 mM, 90% inhibition Hevea brasiliensis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.13
-
DL-mevalonate pH 7.5, 30°C Hevea brasiliensis
2
-
ATP pH 7.5, 30°C Hevea brasiliensis

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ weak stimulation Hevea brasiliensis
Ca2+ can partially replace Mn2+ in activation Hevea brasiliensis
Co2+ weak stimulation Hevea brasiliensis
Co2+ can partially replace Mn2+ in activation Hevea brasiliensis
Fe2+ weak stimulation Hevea brasiliensis
Mg2+ maximal activity at 4 mM Hevea brasiliensis
Mg2+ maximal activity at 4 mM, 77% of activity with Mn2+ Hevea brasiliensis
Mn2+ maximal activation at 1 mM Hevea brasiliensis
Mn2+ divalent cation required for activity Hevea brasiliensis
Mn2+ most active at low concentrations Hevea brasiliensis

Organism

Organism UniProt Comment Textmining
Hevea brasiliensis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
precipitation at pH 4.5, Sephadex G-200, DEAE-Sephadex Hevea brasiliensis

Source Tissue

Source Tissue Comment Organism Textmining
latex
-
Hevea brasiliensis
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.55
-
-
Hevea brasiliensis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + mevalonate no activity with GTP Hevea brasiliensis ADP + phosphomevalonate
-
?
ATP + mevalonate no activity with CTP Hevea brasiliensis ADP + phosphomevalonate
-
?
ATP + mevalonate no activity with ADP Hevea brasiliensis ADP + phosphomevalonate
-
?
ITP + mevalonate as effective as ATP Hevea brasiliensis IDP + phosphomevalonate
-
?
UTP + mevalonate weak activity Hevea brasiliensis UDP + phosphomevalonate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
60 70
-
Hevea brasiliensis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
1 h, little inactivation Hevea brasiliensis
80
-
1 h, 60% loss of activity Hevea brasiliensis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Hevea brasiliensis

pH Range

pH Minimum pH Maximum Comment Organism
6.5 9 approx. 40% of maximal activity at pH 6.5, approx. 70% of maximal activity at pH 9.0 Hevea brasiliensis

pH Stability

pH Stability pH Stability Maximum Comment Organism
4.5 9 1 h, no loss of activity Hevea brasiliensis