Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cysteine | not required for activity | Hevea brasiliensis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CuSO4 | 0.1 mM, 56% inhibition, 1 mM, 77% inhibition | Hevea brasiliensis | |
EDTA | - |
Hevea brasiliensis | |
HgCl2 | 0.1 mM, 90% inhibition | Hevea brasiliensis | |
additional information | not inhibited by iodoacetamide | Hevea brasiliensis | |
N-ethylmaleimide | 0.1 mM, 66% inhibition, 1 mM, 94% inhibition | Hevea brasiliensis | |
p-chloromercuribenzoate | 0.1 mM, 95% inhibition, 1 mM, complete inhibition | Hevea brasiliensis | |
ZnSO4 | 0.1 mM, 90% inhibition | Hevea brasiliensis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.13 | - |
DL-mevalonate | pH 7.5, 30°C | Hevea brasiliensis | |
2 | - |
ATP | pH 7.5, 30°C | Hevea brasiliensis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ba2+ | weak stimulation | Hevea brasiliensis | |
Ca2+ | can partially replace Mn2+ in activation | Hevea brasiliensis | |
Co2+ | weak stimulation | Hevea brasiliensis | |
Co2+ | can partially replace Mn2+ in activation | Hevea brasiliensis | |
Fe2+ | weak stimulation | Hevea brasiliensis | |
Mg2+ | maximal activity at 4 mM | Hevea brasiliensis | |
Mg2+ | maximal activity at 4 mM, 77% of activity with Mn2+ | Hevea brasiliensis | |
Mn2+ | maximal activation at 1 mM | Hevea brasiliensis | |
Mn2+ | divalent cation required for activity | Hevea brasiliensis | |
Mn2+ | most active at low concentrations | Hevea brasiliensis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hevea brasiliensis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
precipitation at pH 4.5, Sephadex G-200, DEAE-Sephadex | Hevea brasiliensis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
latex | - |
Hevea brasiliensis | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.55 | - |
- |
Hevea brasiliensis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + mevalonate | no activity with GTP | Hevea brasiliensis | ADP + phosphomevalonate | - |
? | |
ATP + mevalonate | no activity with CTP | Hevea brasiliensis | ADP + phosphomevalonate | - |
? | |
ATP + mevalonate | no activity with ADP | Hevea brasiliensis | ADP + phosphomevalonate | - |
? | |
ITP + mevalonate | as effective as ATP | Hevea brasiliensis | IDP + phosphomevalonate | - |
? | |
UTP + mevalonate | weak activity | Hevea brasiliensis | UDP + phosphomevalonate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
60 | 70 | - |
Hevea brasiliensis |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
1 h, little inactivation | Hevea brasiliensis |
80 | - |
1 h, 60% loss of activity | Hevea brasiliensis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Hevea brasiliensis |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 9 | approx. 40% of maximal activity at pH 6.5, approx. 70% of maximal activity at pH 9.0 | Hevea brasiliensis |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
4.5 | 9 | 1 h, no loss of activity | Hevea brasiliensis |