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Literature summary for 2.7.1.36 extracted from

  • Soong Lee, C.; O'Sullivan, W.J.O.
    Phosphorothioate analogues of adenosine triphosphate as substrates of the mevalonate kinase reaction (1984), Biochim. Biophys. Acta, 787, 131-137.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
Co-adenosine 5'-O-(2-thio-(R)-triphosphate) pH 8.0 Sus scrofa
0.058
-
Zn-adenosine 5'-O-(2-thio-(S)-triphosphate) pH 8.0 Sus scrofa
0.059
-
Cd-adenosine 5'-O-(2-thio-(R)-triphosphate) pH 8.0 Sus scrofa
0.075
-
Mn-adenosine 5'-O-(2-thio-(S)-triphosphate) pH 8.0 Sus scrofa
0.09
-
Co-adenosine 5'-O-(1-thio-(R)-triphosphate) pH 8.0 Sus scrofa
0.091
-
Ni-adenosine 5'-O-(2-thio-(R)-triphosphate) pH 8.0 Sus scrofa
0.1
-
Co-adenosine 5'-O-(2-thio-(S)-triphosphate) pH 8.0 Sus scrofa
0.12
-
Mg-adenosine 5'-O-(2-thio-(S)-triphosphate) pH 8.0 Sus scrofa
0.12
-
Zn-adenosine 5'-O-(2-thio-(R)-triphosphate) pH 8.0 Sus scrofa
0.14
-
Ca-adenosine 5'-O-(2-thio-(S)-triphosphate) pH 8.0 Sus scrofa
0.14
-
Ni-adenosine 5'-O-(2-thio-(S)-triphosphate) pH 8.0 Sus scrofa
0.16
-
Mg-adenosine 5'-O-(1-thio-(S)-triphosphate) pH 8.0 Sus scrofa
0.2
-
Co-adenosine 5'-O-(1-thio-(S)-triphosphate) pH 8.0 Sus scrofa
0.22
-
Cd-adenosine 5'-O-(1-thio-(R)-triphosphate) pH 8.0 Sus scrofa
0.28
-
Cd-adenosine 5'-O-(1-thio-(S)-triphosphate) pH 8.0 Sus scrofa
0.29
-
Mn-adenosine 5'-O-(2-thio-(R)-triphosphate) pH 8.0 Sus scrofa
0.46
-
Cd-adenosine 5'-O-(2-thio-(S)-triphosphate) pH 8.0 Sus scrofa
0.59
-
Mg-adenosine 5'-O-(2-thio-(R)-triphosphate) pH 8.0 Sus scrofa
0.6
-
Ca-adenosine 5'-O-(2-thio-(R)-triphosphate) pH 8.0 Sus scrofa
0.69
-
ATP pH 8.0 Sus scrofa
2.44
-
Mg-adenosine 5'-O-(1-thio-(R)-triphosphate) pH 8.0 Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine 5'-O-(1-thio-triphosphate) + mevalonate 40% of activity with ATP in the presence of 2 mM Mg2+ Sus scrofa adenosine 5'-O-(1-thio-diphosphate) + 5-phosphomevalonate
-
?
adenosine 5'-O-(2-thio-triphosphate) + mevalonate 54% of activity with ATP in the presence of 2 mM Mg2+ Sus scrofa adenosine 5'-O-(2-thio-diphosphate) + 5-phosphomevalonate
-
?
adenosine 5'-O-(3-thio-triphosphate) + mevalonate 4% of activity with ATP in the presence of 2 mM Mg2+ Sus scrofa adenosine 5'-O-(3-thio-diphosphate) + 5-phosphomevalonate
-
?
ATP + mevalonate ATPgammaS, ATPalphaS and ATPbetaS can act as substrates in presence of different activating divalent metal cations, in the presence of Mg2+ the R diastereomers of both ATPalphaS and ATPbetaS are the preferred substrates, in presence of Cd2+ the S diastereomers are more active Sus scrofa ADP + phosphomevalonate
-
?
Ca-adenosine 5'-O-(2-thio-(R)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Ca-adenosine 5'-O-(2-thio-(S)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Cd-adenosine 5'-O-(1-thio-(R)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Cd-adenosine 5'-O-(1-thio-(S)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Cd-adenosine 5'-O-(2-thio-(R)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Cd-adenosine 5'-O-(2-thio-(S)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Co-adenosine 5'-O-(1-thio-(R)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Co-adenosine 5'-O-(1-thio-(S)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Co-adenosine 5'-O-(2-thio-(R)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Co-adenosine 5'-O-(2-thio-(S)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Mg-adenosine 5'-O-(1-thio-(R)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Mg-adenosine 5'-O-(1-thio-(S)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Mg-adenosine 5'-O-(2-thio-(R)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Mg-adenosine 5'-O-(2-thio-(S)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Mn-adenosine 5'-O-(2-thio-(R)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Mn-adenosine 5'-O-(2-thio-(S)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Ni-adenosine 5'-O-(2-thio-(R)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Ni-adenosine 5'-O-(2-thio-(S)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Zn-adenosine 5'-O-(2-thio-(R)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?
Zn-adenosine 5'-O-(2-thio-(S)-triphosphate) + (R)-mevalonate
-
Sus scrofa ?
-
?