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Literature summary for 2.7.1.33 extracted from

  • Fisher, M.N.; Robishaw, J.D.; Neely, J.R.
    The properties and regulation of pantothenate kinase from rat heart (1985), J. Biol. Chem., 260, 15745-15751.
    View publication on PubMed

General Stability

General Stability Organism
highly unstable upon purification, e.g. successive chromatography Rattus norvegicus
thiol reducing agents stabilize enzyme in solution Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
acetyl-CoA
-
Rattus norvegicus
acyl-CoA-esters
-
Rattus norvegicus
ATP free form Rattus norvegicus
citrate
-
Rattus norvegicus
CoA not reversible by D-carnitine, acetyl-L-carnitine or other carnitine analogs; reversible by L-carnitine Rattus norvegicus
dephospho-CoA
-
Rattus norvegicus
diphosphate
-
Rattus norvegicus
additional information not inhibitory: Mg2+, NADP+; not inhibitory: NAD+ Rattus norvegicus
palmitoyl-CoA
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.018
-
pantothenate pH 7.0, 37°C Rattus norvegicus
0.6
-
ATP pH 7.0, 37°C Rattus norvegicus
0.6
-
ATP ATP in form of MgATP2- Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ Km-value: 0.6 mM Rattus norvegicus
Mg2+ requirement, active substrate: MgATP-complex Rattus norvegicus
additional information nonspecific activation by anions in triethanolamine buffer, pH 7, mostly dicarboxylic acids, not citrate or diphosphate Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-pantothenate Rattus norvegicus
-
ADP + D-4'-phosphopantothenate
-
?
ATP + D-pantothenate Rattus norvegicus Sprague-Dawley
-
ADP + D-4'-phosphopantothenate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprague-Dawley
-
Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-

Source Tissue

Source Tissue Comment Organism Textmining
heart ventricular muscle Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00171
-
pH 7.0, 37°C Rattus norvegicus

Storage Stability

Storage Stability Organism
-65°C, 3 mg partially purified protein/ml, at least 4 months Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-pantothenate
-
Rattus norvegicus ADP + (R)-4'-phosphopantothenate
-
?
ATP + (R)-pantothenate
-
Rattus norvegicus Sprague-Dawley ADP + (R)-4'-phosphopantothenate
-
?
ATP + D-pantothenate
-
Rattus norvegicus ADP + D-4'-phosphopantothenate
-
?
ATP + D-pantothenate
-
Rattus norvegicus Sprague-Dawley ADP + D-4'-phosphopantothenate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 9 broad, highest activity in 50 mM phosphate buffer Rattus norvegicus