Literature summary for 2.7.1.32 extracted from

Gruber, J.; See Too, W.C.; Wong, M.T.; Lavie, A.; McSorley, T.; Konrad, M.
Balance of human choline kinase isoforms is critical for cell cycle regulation: implications for the development of choline kinase-targeted cancer therapy (2012), FEBS J., 279, 1915-1928.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	isoform CKalpha	Homo sapiens	5737	-
nucleoplasm	isoform CKalpha	Homo sapiens	5654	-
nucleus	nuclear localization probability of 60.9% is detected for isoform CKalpha2 and of 52.2% for CKalpha1	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + choline	-	Homo sapiens	ADP + phosphocholine	-	?

Synonyms

Synonyms	Comment	Organism
CKalpha1	isoform	Homo sapiens
CKalpha2	isoform	Homo sapiens
CKbeta1	isoform	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	silencing of CKalpha leads to a lethal phenotype with aberrant mitotic arrest and subsequent apoptosis, and is rescued by simultaneous knockdown of CKalpha and CKbeta isoforms	Homo sapiens
physiological function	levels of CKalpa and CKbeta play an essential role in progression through mitosis, but not in resting cells or during DNA replication	Homo sapiens

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Release 2023.1 (January 2023)