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Literature summary for 2.7.1.30 extracted from

  • Hibuse, T.; Maeda, N.; Funahashi, T.; Yamamoto, K.; Nagasawa, A.; Mizunoya, W.; Kishida, K.; Inoue, K.; Kuriyama, H.; Nakamura, T.; Fushiki, T.; Kihara, S.; Shimomura, I.
    Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase (2005), Proc. Natl. Acad. Sci. USA, 102, 10993-10998.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information Aqp7-knockout mice Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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wild type and Aqp7 knockout male mice and mouse 3T3-L1 cell line
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Source Tissue

Source Tissue Comment Organism Textmining
adipocyte There is no difference in glycerol mRNA level between control 3T3-L1 adipocytes and 3T3-L1 Aqp7-RNAi transfected adipocytes, whereas a 4fold enzymatic activation of glycerol kinase is observable in Aqp7 knockout adipocytes (activity assay: 50 mM TrisHCl, pH 7.2, 5 mM ATP, 10 mM MgCl2, 100 mM KCl, 2.5 mM DTT, 4 mM glycerol, 500 microM 3H-glycerol, for 90 min at 37°C). Mus musculus
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adipose There is no difference in the mRNA levels and activities of adipose glycerol kinase between Aqp7-/- and Aqp7+/+ mice at 10 weeks of age. Adipose glycerol kinase activity of Aqp7-/- mice is significantly higher than that of wild type mice under the 12 h fasting state. The fat pads of the Aqp7-/- knockout mice are significantily larger than those of wild type mice at 20 weeks of age. Mus musculus
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blood plasma Aqp7-/- knockout mice have significantly lower plasma glycerol level under 12 h fasting conditions. Mus musculus
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Synonyms

Synonyms Comment Organism
GYK glycerol kinase Mus musculus