Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.21 extracted from

  • Leyton, J.; Smith, G.; Lees, M.; Perumal, M.; Nguyen, Q.D.; Aigbirhio, F.I.; Golovko, O.; He, Q.; Workman, P.; Aboagye, E.O.
    Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901 (2008), Mol. Cancer Ther., 7, 3112-3121.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SK-MEL-28 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + thymidine
-
Homo sapiens ADP + thymidine 5'-phosphate
-
?

Synonyms

Synonyms Comment Organism
thymidine kinase I
-
Homo sapiens
TK1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 0.001 mM of the mitogenic extracellular kinase 1/2 inhibitor PD0325901 rapidly decreases thymidine kinase 1 protein levels and mRNA expression in SKMEL-28 human melanoma cells with maximum reduction at 48 h posttreatment down