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Literature summary for 2.7.1.21 extracted from

  • Azab, W.; Tsujimura, K.; Kato, K.; Arii, J.; Morimoto, T.; Kawaguchi, Y.; Tohya, Y.; Matsumura, T.; Akashi, H.
    Characterization of a thymidine kinase-deficient mutant of equine herpesvirus 4 and in vitro susceptibility of the virus to antiviral agents (2010), Antiviral Res., 85, 389-395.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + thymidine Equid alphaherpesvirus 4
-
 ADP + thymidine 5'-phosphate
-
 ?
ATP + thymidine Equid alphaherpesvirus 4 TH20p
-
 ADP + thymidine 5'-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Equid alphaherpesvirus 4
-
-
-
Equid alphaherpesvirus 4 TH20p
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + thymidine
-
 Equid alphaherpesvirus 4 ADP + thymidine 5'-phosphate
-
 ?
ATP + thymidine
-
 Equid alphaherpesvirus 4 TH20p ADP + thymidine 5'-phosphate
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Equid alphaherpesvirus 4

General Information

General Information Comment Organism
malfunction the thymidine kinase-deletion mutant WA79DELTATK shows more than 20fold increase in sensitivity towards acyclovir and is insensitive to ganciclovir Equid alphaherpesvirus 4
physiological function the virus-encoded thymidine kinase is an important determinant of the virus susceptibility to nucleoside analogues Equid alphaherpesvirus 4