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Literature summary for 2.7.1.21 extracted from

  • Perez-Perez, M.J.; Hernandez, A.I.; Priego, E.M.; Rodriguez-Barrios, F.; Gago, F.; Camarasa, M.J.; Balzarini, J.
    Mitochondrial thymidine kinase inhibitors (2005), Curr. Top. Med. Chem., 5, 1205-1219.
    View publication on PubMed
Search for more literature for 2.7.1.21

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Human alphaherpesvirus 1
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl 3,3-dimethylbutanoate IC50: 0.028 mM Homo sapiens
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl 3,3-dimethylbutanoate IC50: above 0.5 mM Human alphaherpesvirus 1
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl benzoate IC50: 0.03 mM Homo sapiens
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl benzoate IC50: above 0.5 mM Human alphaherpesvirus 1
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl diphenylacetate IC50: 0.0046 mM Homo sapiens
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl diphenylacetate IC50: 0.281 mM Human alphaherpesvirus 1
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl dodecanoate IC50: 0.019 mM Homo sapiens
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl dodecanoate IC50: above 0.5 mM Human alphaherpesvirus 1
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl heptanoate IC50: 0.011 mM Homo sapiens
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl heptanoate IC50: 0.42 mM Human alphaherpesvirus 1
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl pivalate IC50: 0.04 mM Homo sapiens
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl pivalate IC50: above 0.5 mM Human alphaherpesvirus 1
(4E)-N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide IC50: 0.265 mM Homo sapiens
(4E)-N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide IC50: above 0.5 mM Human alphaherpesvirus 1
(4E)-N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide IC50: 0.371 mM Homo sapiens
(4E)-N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide IC50: above 0.5 mM Human alphaherpesvirus 1
1-[(2Z)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione IC50: 0.18 mM Homo sapiens
1-[(2Z)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione IC50: 0.18 mM Human alphaherpesvirus 1
1-[(2Z)-4-(benzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione IC50: 0.057 mM Homo sapiens
1-[(2Z)-4-(benzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione IC50: 0.057 mM Human alphaherpesvirus 1
1-[(2Z)-4-(benzyloxy)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione IC50: 0.022 mM Homo sapiens
1-[(2Z)-4-(benzyloxy)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione IC50: above 0.5 mM Human alphaherpesvirus 1
1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione IC50: 0.0035 mM; IC50: above 0.5 mM Homo sapiens
1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione IC50: 0.0035 mM Human alphaherpesvirus 1
1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-5,6-dihydrothymine IC50: 0.01 mM Homo sapiens
1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-5,6-dihydrothymine IC50: above 0.5 mM Human alphaherpesvirus 1
1-[(2Z)-4-hydroxybut-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione IC50: 0.173 mM Homo sapiens
1-[(2Z)-4-hydroxybut-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione IC50: 0.224 mM Human alphaherpesvirus 1
1-[2,3-dihydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione IC50: 0.017 mM Homo sapiens
1-[2,3-dihydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione IC50: 0.013 mM Human alphaherpesvirus 1
1-[3-hydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione IC50: 0.0036 mM Homo sapiens
1-[3-hydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione IC50: 0.0012 mM Human alphaherpesvirus 1
2-(4-chlorophenyl)-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide IC50: 0.023 mM Homo sapiens
2-(4-chlorophenyl)-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide IC50: 0.198 mM Human alphaherpesvirus 1
2-biphenyl-4-yl-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide IC50: 0.0041 mM Homo sapiens
2-biphenyl-4-yl-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide IC50: 0.119 mM Human alphaherpesvirus 1
3'-O-ethyl-2'-deoxyuridine
-
 Homo sapiens
3'-O-methyl-2'-deoxyuridine
-
 Homo sapiens
3'-spiro-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)-5-methyluridine inhibits phosphorylation of 2'-deoxythymidine, IC50: 0.0046 mM Homo sapiens
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylbutanamide IC50: 0.44 mM Homo sapiens
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylbutanamide IC50: 0.175 mM Human alphaherpesvirus 1
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-[2-oxo-2-(tritylamino)ethyl]butanamide IC50: 0.194 mM Homo sapiens
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-[2-oxo-2-(tritylamino)ethyl]butanamide IC50: 0.191 mM Human alphaherpesvirus 1
5'-O-(4,4'-dimethoxytrityl)thymidine IC50: 0.468 mM Homo sapiens
5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil IC50: 0.0013 mM; IC50: 0.1 mM Homo sapiens
5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil IC50: above 0.5 mM Human alphaherpesvirus 1
5-(E)-(2-bromovinyl)uridine inhibits phosphorylation of 2'-deoxythymidine Homo sapiens
5-ethyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil IC50: 0.02 mM Homo sapiens
5-ethyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil IC50: above 0.5 mM Human alphaherpesvirus 1
5-iodo-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil IC50: 0.0046 mM Homo sapiens
5-iodo-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil IC50: 0.048 mM Human alphaherpesvirus 1
5-methyl-1-[(2E)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione IC50: 0.025 mM Homo sapiens
5-methyl-1-[(2E)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione IC50: 0.003 mM Human alphaherpesvirus 1
5-methyl-1-[(2Z)-4-(4-methylpiperazin-1-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione IC50: 0.491 mM Homo sapiens
5-methyl-1-[(2Z)-4-(4-methylpiperazin-1-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione IC50: 0.491 mM Human alphaherpesvirus 1
5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione IC50: 0.0023 mM; IC50: above 0.5 mM Homo sapiens
5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione IC50: 0.0023 mM Human alphaherpesvirus 1
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-cytosine IC50: 0.484 mM Homo sapiens
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-cytosine IC50: above 0.5 mM Human alphaherpesvirus 1
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione IC50: 0.0015 mM; IC50: above 0.1 mM Homo sapiens
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione IC50: 0.045 mM Human alphaherpesvirus 1
5-methyl-1-[4-(trityloxy)but-2-yn-1-yl]pyrimidine-2,4(1H,3H)-dione IC50: 0.404 mM Homo sapiens
5-methyl-1-[4-(trityloxy)but-2-yn-1-yl]pyrimidine-2,4(1H,3H)-dione IC50: 0.0031 mM Human alphaherpesvirus 1
5-methyl-1-[4-(trityloxy)butyl]pyrimidine-2,4(1H,3H)-dione IC50: 0.0033 mM Homo sapiens
5-methyl-1-[4-(trityloxy)butyl]pyrimidine-2,4(1H,3H)-dione IC50: 0.01 mM Human alphaherpesvirus 1
5-[(E)-2-bromoethenyl]-2'-O-decanoyluridine competitive with respect to 2'-deoxythymidine, IC50: 0.0012 mm Homo sapiens
5-[(E)-2-bromoethenyl]-2'-O-octanoyluridine IC50: 0.006 mM Homo sapiens
6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylhexanamide IC50: 0.019 mM Homo sapiens
6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylhexanamide IC50: 0.0034 mM Human alphaherpesvirus 1
9-[(2Z)-4-(trityloxy)but-2-en-1-yl]-guanine IC50: above 0.5 mM Homo sapiens
9-[(2Z)-4-(trityloxy)but-2-en-1-yl]-guanine IC50: above 0.5 mM Human alphaherpesvirus 1
N-(2-cyanoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide IC50: 0.46 mM Homo sapiens
N-(2-cyanoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide IC50: above 0.5 mM Human alphaherpesvirus 1
N-(2-cyanoethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide IC50: 0.353 mM Homo sapiens
N-(2-cyanoethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide IC50: above 0.5 mM Human alphaherpesvirus 1
N-(2-[[cyano(phenyl)methyl]amino]-2-oxoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide IC50: 0.318 mM Homo sapiens
N-(2-[[cyano(phenyl)methyl]amino]-2-oxoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide IC50: above 0.5 mM Human alphaherpesvirus 1
N-(cyanomethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide IC50: 0.268 mM Homo sapiens
N-(cyanomethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide IC50: above 0.5 mM Human alphaherpesvirus 1
N-(diphenylmethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide IC50: 0.238 mM Homo sapiens
N-(diphenylmethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide IC50: above 0.5 mM Human alphaherpesvirus 1
N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide IC50: 0.038 mM Homo sapiens
N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide IC50: 0.043 mM Human alphaherpesvirus 1
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-2,2-diphenylacetamide IC50: 0.027 mM Homo sapiens
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-2,2-diphenylacetamide IC50: 0.115 mM Human alphaherpesvirus 1
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-3-(trifluoromethyl)benzamide IC50: 0.028 mM Homo sapiens
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-3-(trifluoromethyl)benzamide IC50: 0.072 mM Human alphaherpesvirus 1
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-9H-xanthene-9-carboxamide IC50: 0.033 mM Homo sapiens
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-9H-xanthene-9-carboxamide IC50: 0.131 mM Human alphaherpesvirus 1
N-[2-[(diphenylmethyl)amino]-2-oxoethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide IC50: 0.287 mM Homo sapiens
N-[2-[(diphenylmethyl)amino]-2-oxoethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide IC50: above 0.5 mM Human alphaherpesvirus 1
N-[cyano(phenyl)methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide IC50: 0.208 mM Homo sapiens
N-[cyano(phenyl)methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide IC50: 0.495 mM Human alphaherpesvirus 1
N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide IC50: 0.075 mM Homo sapiens
N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide IC50: 0.275 mM Human alphaherpesvirus 1
N3-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-thymine IC50: above 0.5 mM Homo sapiens
N3-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-thymine IC50: above 0.5 mM Human alphaherpesvirus 1

Organism

Organism UniProt Comment Textmining
Homo sapiens O00142
-
-
Homo sapiens P04183
-
-
Human alphaherpesvirus 1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-(beta-D-arabinofuranosyl)thymine
-
 Human alphaherpesvirus 1 ADP + 1-(beta-D-arabinofuranosyl)thymine 5'-phosphate
-
 ?
ATP + 1-(beta-D-arabinofuranosyl)thymine
-
 Homo sapiens ADP + 1-(beta-D-arabinofuranosyl)thymine 5'-phosphate
-
 ?
ATP + 2'-deoxythymidine
-
 Human alphaherpesvirus 1 ADP + 2'-deoxythymidine 5'-phosphate
-
 ?
ATP + 2'-deoxythymidine
-
 Homo sapiens ADP + 2'-deoxythymidine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Mt-TK
-
 Homo sapiens
thymidine kinase 2, mitochondrial
-
 Homo sapiens
TK-2
-
 Homo sapiens
TK1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0012
-
 IC50: 0.0012 mM Human alphaherpesvirus 1 1-[3-hydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.0012
-
 competitive with respect to 2'-deoxythymidine, IC50: 0.0012 mM Homo sapiens 5-[(E)-2-bromoethenyl]-2'-O-decanoyluridine
0.0013
-
 IC50: 0.0013 mM Homo sapiens 5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
0.0015
-
 IC50: 0.0015 mM Homo sapiens 5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
0.0023
-
 IC50: 0.0023 mM Human alphaherpesvirus 1 5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
0.0023
-
 IC50: 0.0023 mM Homo sapiens 5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
0.003
-
 IC50: 0.003 mM Human alphaherpesvirus 1 5-methyl-1-[(2E)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
0.0031
-
 IC50: 0.0031 mM Human alphaherpesvirus 1 5-methyl-1-[4-(trityloxy)but-2-yn-1-yl]pyrimidine-2,4(1H,3H)-dione
0.0033
-
 IC50: 0.0033 mM Homo sapiens 5-methyl-1-[4-(trityloxy)butyl]pyrimidine-2,4(1H,3H)-dione
0.0034
-
 IC50: 0.0034 mM Human alphaherpesvirus 1 6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylhexanamide
0.0035
-
 IC50: 0.0035 mM Human alphaherpesvirus 1 1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.0035
-
 IC50: 0.0035 mM Homo sapiens 1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.0036
-
 IC50: 0.0036 mM Homo sapiens 1-[3-hydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.0041
-
 IC50: 0.0041 mM Homo sapiens 2-biphenyl-4-yl-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
0.0046
-
 IC50: 0.0046 mM Homo sapiens 5-iodo-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
0.0046
-
 IC50: 0.0046 mM Homo sapiens (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl diphenylacetate
0.0046
-
 inhibits phosphorylation of 2'-deoxythymidine, IC50: 0.0046 mM Homo sapiens 3'-spiro-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)-5-methyluridine
0.006
-
 IC50: 0.006 mM Homo sapiens 5-[(E)-2-bromoethenyl]-2'-O-octanoyluridine
0.01
-
 IC50: 0.01 mM Human alphaherpesvirus 1 5-methyl-1-[4-(trityloxy)butyl]pyrimidine-2,4(1H,3H)-dione
0.01
-
 IC50: 0.01 mM Homo sapiens 1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-5,6-dihydrothymine
0.011
-
 IC50: 0.011 mM Homo sapiens (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl heptanoate
0.013
-
 IC50: 0.013 mM Human alphaherpesvirus 1 1-[2,3-dihydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.017
-
 IC50: 0.017 mM Homo sapiens 1-[2,3-dihydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.019
-
 IC50: 0.019 mM Homo sapiens (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl dodecanoate
0.019
-
 IC50: 0.019 mM Homo sapiens 6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylhexanamide
0.02
-
 IC50: 0.02 mM Homo sapiens 5-ethyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
0.022
-
 IC50: 0.022 mM Homo sapiens 1-[(2Z)-4-(benzyloxy)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.023
-
 IC50: 0.023 mM Homo sapiens 2-(4-chlorophenyl)-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
0.025
-
 IC50: 0.025 mM Homo sapiens 5-methyl-1-[(2E)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
0.027
-
 IC50: 0.027 mM Homo sapiens N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-2,2-diphenylacetamide
0.028
-
 IC50: 0.028 mM Homo sapiens (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl 3,3-dimethylbutanoate
0.028
-
 IC50: 0.028 mM Homo sapiens N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-3-(trifluoromethyl)benzamide
0.03
-
 IC50: 0.03 mM Homo sapiens (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl benzoate
0.033
-
 IC50: 0.033 mM Homo sapiens N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-9H-xanthene-9-carboxamide
0.038
-
 IC50: 0.038 mM Homo sapiens N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
0.04
-
 IC50: 0.04 mM Homo sapiens (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl pivalate
0.043
-
 IC50: 0.043 mM Human alphaherpesvirus 1 N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
0.045
-
 IC50: 0.045 mM Human alphaherpesvirus 1 5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
0.048
-
 IC50: 0.048 mM Human alphaherpesvirus 1 5-iodo-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
0.057
-
 IC50: 0.057 mM Human alphaherpesvirus 1 1-[(2Z)-4-(benzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.057
-
 IC50: 0.057 mM Homo sapiens 1-[(2Z)-4-(benzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.072
-
 IC50: 0.072 mM Human alphaherpesvirus 1 N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-3-(trifluoromethyl)benzamide
0.075
-
 IC50: 0.075 mM Homo sapiens N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
0.1
-
 IC50: 0.1 mM Homo sapiens 5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
0.1
-
 IC50: above 0.1 mM Homo sapiens 5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
0.115
-
 IC50: 0.115 mM Human alphaherpesvirus 1 N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-2,2-diphenylacetamide
0.119
-
 IC50: 0.119 mM Human alphaherpesvirus 1 2-biphenyl-4-yl-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
0.131
-
 IC50: 0.131 mM Human alphaherpesvirus 1 N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-9H-xanthene-9-carboxamide
0.173
-
 IC50: 0.173 mM Homo sapiens 1-[(2Z)-4-hydroxybut-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.175
-
 IC50: 0.175 mM Human alphaherpesvirus 1 4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylbutanamide
0.18
-
 IC50: 0.18 mM Human alphaherpesvirus 1 1-[(2Z)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.18
-
 IC50: 0.18 mM Homo sapiens 1-[(2Z)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.191
-
 IC50: 0.191 mM Human alphaherpesvirus 1 4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-[2-oxo-2-(tritylamino)ethyl]butanamide
0.194
-
 IC50: 0.194 mM Homo sapiens 4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-[2-oxo-2-(tritylamino)ethyl]butanamide
0.198
-
 IC50: 0.198 mM Human alphaherpesvirus 1 2-(4-chlorophenyl)-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
0.208
-
 IC50: 0.208 mM Homo sapiens N-[cyano(phenyl)methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
0.224
-
 IC50: 0.224 mM Human alphaherpesvirus 1 1-[(2Z)-4-hydroxybut-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.238
-
 IC50: 0.238 mM Homo sapiens N-(diphenylmethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
0.265
-
 IC50: 0.265 mM Homo sapiens (4E)-N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide
0.268
-
 IC50: 0.268 mM Homo sapiens N-(cyanomethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
0.275
-
 IC50: 0.275 mM Human alphaherpesvirus 1 N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
0.281
-
 IC50: 0.281 mM Human alphaherpesvirus 1 (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl diphenylacetate
0.287
-
 IC50: 0.287 mM Homo sapiens N-[2-[(diphenylmethyl)amino]-2-oxoethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
0.318
-
 IC50: 0.318 mM Homo sapiens N-(2-[[cyano(phenyl)methyl]amino]-2-oxoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
0.353
-
 IC50: 0.353 mM Homo sapiens N-(2-cyanoethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
0.371
-
 IC50: 0.371 mM Homo sapiens (4E)-N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide
0.404
-
 IC50: 0.404 mM Homo sapiens 5-methyl-1-[4-(trityloxy)but-2-yn-1-yl]pyrimidine-2,4(1H,3H)-dione
0.42
-
 IC50: 0.42 mM Human alphaherpesvirus 1 (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl heptanoate
0.44
-
 IC50: 0.44 mM Homo sapiens 4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylbutanamide
0.46
-
 IC50: 0.46 mM Homo sapiens N-(2-cyanoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
0.468
-
 IC50: 0.468 mM Homo sapiens 5'-O-(4,4'-dimethoxytrityl)thymidine
0.484
-
 IC50: 0.484 mM Homo sapiens 5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-cytosine
0.491
-
 IC50: 0.491 mM Human alphaherpesvirus 1 5-methyl-1-[(2Z)-4-(4-methylpiperazin-1-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
0.491
-
 IC50: 0.491 mM Homo sapiens 5-methyl-1-[(2Z)-4-(4-methylpiperazin-1-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
0.495
-
 IC50: 0.495 mM Human alphaherpesvirus 1 N-[cyano(phenyl)methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
0.5
-
 IC50: above 0.5 mM Homo sapiens 1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.5
-
 IC50: above 0.5 mM Homo sapiens 5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 9-[(2Z)-4-(trityloxy)but-2-en-1-yl]-guanine
0.5
-
 IC50: above 0.5 mM Homo sapiens 9-[(2Z)-4-(trityloxy)but-2-en-1-yl]-guanine
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-cytosine
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 N3-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-thymine
0.5
-
 IC50: above 0.5 mM Homo sapiens N3-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-thymine
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 5-ethyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-5,6-dihydrothymine
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl pivalate
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl 3,3-dimethylbutanoate
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl dodecanoate
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl benzoate
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 1-[(2Z)-4-(benzyloxy)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 N-(2-cyanoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 N-(diphenylmethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 N-(2-[[cyano(phenyl)methyl]amino]-2-oxoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 N-[2-[(diphenylmethyl)amino]-2-oxoethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 N-(cyanomethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 N-(2-cyanoethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 (4E)-N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide
0.5
-
 IC50: above 0.5 mM Human alphaherpesvirus 1 (4E)-N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide