Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-bromodeoxyuridine | competitive to thymidine | Physarum polycephalum | |
5-fluorodeoxyuridine | competitive to thymidine | Physarum polycephalum | |
5-iododeoxyuridine | competitive to thymidine | Physarum polycephalum | |
ADP | competitive to ATP | Physarum polycephalum | |
Caffeine | competitive to ATP | Physarum polycephalum | |
deoxyuridine | - |
Physarum polycephalum | |
dGDP | competitive to ATP | Physarum polycephalum | |
dTDP | competitive to ATP | Physarum polycephalum | |
dTMP | competitive to ATP | Physarum polycephalum | |
dTTP | non-competitive with thymidine, competitive to ATP | Physarum polycephalum | |
dUTP | competitive to ATP | Physarum polycephalum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Physarum polycephalum |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | 7.5-10 mM, required | Physarum polycephalum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Physarum polycephalum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Physarum polycephalum |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasmodium | - |
Physarum polycephalum | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
100 | - |
- |
Physarum polycephalum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + thymidine | ATP can be substituted by dATP | Physarum polycephalum | ADP + dTMP | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 9 | - |
Physarum polycephalum |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 9.5 | less than 70% of maximal activity above and below | Physarum polycephalum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | 0.0045 | 5-iododeoxyuridine | pH 7.5, 27°C | Physarum polycephalum | |
0.0015 | 0.0055 | 5-bromodeoxyuridine | pH 7.5, 27°C | Physarum polycephalum | |
0.014 | 0.036 | dTTP | pH 7.5, 27°C | Physarum polycephalum | |
0.06 | 0.096 | 5-fluorodeoxyuridine | pH 7.5, 27°C | Physarum polycephalum | |
0.27 | 1.54 | deoxyuridine | pH 7.5, 27°C | Physarum polycephalum | |
0.5 | 0.65 | dTDP | pH 7.5, 27°C | Physarum polycephalum | |
3.6 | 4.7 | dTMP | pH 7.5, 27°C | Physarum polycephalum |