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Literature summary for 2.7.1.154 extracted from

  • Ono, F.; Nakagawa, T.; Saito, S.; Owada, Y.; Sakagami, H.; Goto, K.; Suzuki, M.; Matsuno, S.; Kondo, H.
    A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration (1998), J. Biol. Chem., 273, 7731-7736.
    View publication on PubMed
Search for more literature for 2.7.1.154

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS-7 cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Mn2+ 3.5 mM, instead of Mg2+, almost complete inhibition Rattus norvegicus
Nonidet P-40 0.5%, almost complete inhibition Rattus norvegicus
Triton X-100 0.5%, almost complete inhibition Rattus norvegicus
Wortmannin IC50: 12 nM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
juxtanuclear Golgi region at high levels Rattus norvegicus
-
-
nuclear membrane at low level Rattus norvegicus 31965
-
plasma membrane at low level Rattus norvegicus 5886
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
170972
-
 x * 170972, calculation from nucleotide sequence Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus O70173 PI3-C2gamma
-

Source Tissue

Source Tissue Comment Organism Textmining
liver PI3K-IIgamma mRNA expression is confined to the liver throughout the development with much higher expression in adult liver than in fetal liver. Expression increases during liver regeneration after partial hepatectomy. PI3K-gamma may function mainly in highly differentiated hepatic cells Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol-4-phosphate
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
 ?
ATP + phosphatidylinositol
-
 Rattus norvegicus ADP + phosphatidylinositol 3-phosphate
-
 ?
additional information no activity with phosphatidylinositol 4,5-diphosphate Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 170972, calculation from nucleotide sequence Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000012
-
 IC50: 12 nM Rattus norvegicus Wortmannin