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Literature summary for 2.7.1.153 extracted from

  • Ueki, K.; Fruman, D.A.; Brachmann, S.M.; Tseng, Y.H.; Cantley, L.C.; Kahn, C.R.
    Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival (2002), Mol. Cell. Biol., 22, 965-977.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine reduction of regulatory subunit p85alpha as a therapeutic target for enhancing insulin-like growth factor 1/insulin signaling, prolongation of cell survival, and protection against apoptosis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information heterozygous disruption of p85alpha regulatory subunit, increase in enzyme activity and decrease in apoptosis by insulin-like growth factor 1 through upregulated phosphatidylinositol (3,4,5)-triphosphate production. Complete depletion of regulatory subunit p85alpha results in significantly increased apoptosis due to reduced enzyme-dependent signaling Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast embryonic fibroblast cell culture Mus musculus
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Subunits

Subunits Comment Organism
More enzyme is comprised of p110 catalytic subunit and a regulatory subunit often derived of p85. In wild-type cells, p85 subunit is more abundant than p110 Mus musculus

Synonyms

Synonyms Comment Organism
Pik3r1
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Mus musculus