Application | Comment | Organism |
---|---|---|
medicine | reduction of regulatory subunit p85alpha as a therapeutic target for enhancing insulin-like growth factor 1/insulin signaling, prolongation of cell survival, and protection against apoptosis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | heterozygous disruption of p85alpha regulatory subunit, increase in enzyme activity and decrease in apoptosis by insulin-like growth factor 1 through upregulated phosphatidylinositol (3,4,5)-triphosphate production. Complete depletion of regulatory subunit p85alpha results in significantly increased apoptosis due to reduced enzyme-dependent signaling | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | embryonic fibroblast cell culture | Mus musculus | - |
Subunits | Comment | Organism |
---|---|---|
More | enzyme is comprised of p110 catalytic subunit and a regulatory subunit often derived of p85. In wild-type cells, p85 subunit is more abundant than p110 | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
Pik3r1 | - |
Mus musculus |