Literature summary for 2.7.1.153 extracted from

Klippel, A.; Escobedo, J.A.; Hirano, M.; Williams, L.T.
The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity (1994), Mol. Cell. Biol., 14, 2675-2685.

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Protein Variants

Protein Variants	Comment	Organism
additional information	expression of regulatory protein p85 102 amino acid binding domain plus catalytic subunit p110 leads to fully active enzyme complex	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P42337	recombinant enzyme	-

Subunits

Subunits	Comment	Organism
More	interactive domains in subunits p85 and p110 responsible for binding to each other are less than 103 and 124 amino acids, respectively. Association of subunits is critical for enzyme activity	Mus musculus

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Release 2023.1 (January 2023)