Inhibitors | Comment | Organism | Structure |
---|---|---|---|
YM201636 | a selective PIKfyve inhibitor | Didelphis sp. | |
YM201636 | a selective PIKfyve inhibitor | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Didelphis sp. | 16020 | - |
membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Didelphis sp. | |
Mg2+ | required | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | Didelphis sp. | - |
ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | Rattus norvegicus | - |
ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Didelphis sp. | - |
gene PIKfyve | - |
Rattus norvegicus | D3ZYT8 | gene PIKfyve | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | AMP-activated protein kinase stimulates the enzyme by phosphorylation at Ser307 both in vitro and in intact cells | Didelphis sp. |
phosphoprotein | AMP-activated protein kinase stimulates the enzyme by phosphorylation at Ser307 both in vitro and in intact cells | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | - |
Rattus norvegicus | - |
epitrochlearis muscle | the enzyme is increased in contracting versus resting muscles | Rattus norvegicus | - |
kidney | - |
Didelphis sp. | - |
myotube | - |
Rattus norvegicus | - |
skeletal muscle | - |
Didelphis sp. | - |
skeletal muscle | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
Didelphis sp. | ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
Rattus norvegicus | ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FYVE domain-containing phosphatidylinositol 3-phosphate 5-kinase | - |
Didelphis sp. |
FYVE domain-containing phosphatidylinositol 3-phosphate 5-kinase | - |
Rattus norvegicus |
phosphatidylinositol 3-phosphate 5-kinase | - |
Didelphis sp. |
phosphatidylinositol 3-phosphate 5-kinase | - |
Rattus norvegicus |
PIKfyve | - |
Didelphis sp. |
PIKfyve | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Didelphis sp. | |
ATP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition reduces contraction- and AICAriboside (5-amino-4-imidazolecarboxamide riboside)-stimulated glucose uptake. PIKfyve knockdown in C2C12 myotubes reduced AICAriboside-stimulated glucose transport | Rattus norvegicus |
physiological function | the enzyme activity is implicated in be involved in contraction/AMPK (AMP-activated protein kinase)-stimulated glucose uptake in skeletal muscle rather than insulin-stimulated glucose uptake. The enzyme is an AMPK substrate whose phosphorylation at Ser307 promotes PIKfyve translocation to endosomes for PtdIns(3,5)P2 synthesis to facilitate GLUT4 (glucose transporter 4) translocation | Rattus norvegicus |
physiological function | the enzyme activity is required for the stimulation of skeletal muscle glucose uptake by contraction/AMPK activation. In opossum kidney cells, wild-type, but not S307A mutant, PIKfyve is recruited to endosomal vesicles in response to AMPK activation | Didelphis sp. |