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Literature summary for 2.7.1.149 extracted from
- Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization (2013), Biochem. J., 454, 49-57.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D280K | inactive | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00394 | - |
ATP | isoform PI5P4Kalpha, at pH 7.4 and 22°C | Homo sapiens |  |
| 0.00394 | - |
ATP | isoform PI5P4Kalpha, at pH 7.4 and 30°C | Homo sapiens | |
| 0.06705 | - |
ATP | isoform PI5P4Kbeta, at pH 7.4 and 22°C | Homo sapiens | |
| 0.06705 | - |
ATP | isoform PI5P4Kbeta, at pH 7.4 and 30°C | Homo sapiens | |
| 0.09418 | - |
ATP | isoform PI5P4Kgamma, at pH 7.4 and 22°C | Homo sapiens | |
| 0.09418 | - |
ATP | isoform PI5P4Kgamma, at pH 7.4 and 30°C | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Homo sapiens | 5634 | - |
| nucleus | isoform PI5P4Kbeta | Homo sapiens | 5634 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 47000 | - |
x * 47000, calculated from amino acid sequence | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P48426 | - |
- |
| Homo sapiens | P78356 | - |
- |
| Homo sapiens | Q8TBX8 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 47000, calculated from amino acid sequence | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phosphatidylinositol 5-phosphate 4-kinase | - |
Homo sapiens |
| PI5P4Kalpha | - |
Homo sapiens |
| PI5P4Kalpha | isoform | Homo sapiens |
| PI5P4Kbeta | - |
Homo sapiens |
| PI5P4Kbeta | isoform | Homo sapiens |
| PI5P4Kgamma | - |
Homo sapiens |
| PI5P4Kgamma | isoform | Homo sapiens |
| PtdIns5P 4-kinase | - |
Homo sapiens |
| PtdIns5P4-kinase | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00000572 | - |
ATP | isoform PI5P4Kgamma, at pH 7.4 and 22°C | Homo sapiens | |
| 0.000955 | - |
ATP | isoform PI5P4Kbeta, at pH 7.4 and 22°C | Homo sapiens | |
| 0.0105 | - |
ATP | isoform PI5P4Kalpha, at pH 7.4 and 22°C | Homo sapiens | |
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Release 2023.1 (January 2023)
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