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Literature summary for 2.7.1.137 extracted from
- Roles of Pichia pastoris Uvrag in vacuolar protein sorting and the phosphatidylinositol 3-kinase complex in phagophore elongation in autophagy pathways (2010), Autophagy, 6, 86-99.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Atg14 | PAS localization, along with that of the other components of PI3K complex I, requires Atg14 | Komagataella pastoris | |
| Atg6 | in the absence of PpAtg6, PpUvrag-GFP as well as PpAtg8 fully mislocalized to the cytosol | Komagataella pastoris | |
| Vps15 | - |
Komagataella pastoris | |
| Vps38 | the endosomal localization of Atg6 and the other components of PI3K complex II requires Vps38 | Komagataella pastoris |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| phagophore | PI3K complex localization during the elongation of the phagophor | Komagataella pastoris | 61908 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Komagataella pastoris | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PI3K | - |
Komagataella pastoris |
| VPS34 | - |
Komagataella pastoris |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Atg6/Beclin 1, the phosphatidylinositol 3-kinase Vps34, and associated proteins Atg6 and Vps15 have direct or indirect roles in autophagic pathways. Roles of PI3K complex proteins and PpUvrag in autophagy, autophagy-related and the VPS pathways, overview. PpUvrag is required for the vacuolar sorting of PpCPY and in its absence PpCPY is mis-sorted | Komagataella pastoris |
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