Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-myo-inositol 1,4,5-trisphosphate | strong inhibition, purified recombinant enzyme, IC50 value is 0.003 mM in absence of Ca2+ | Rattus norvegicus | |
D-scyllo-inositol 1,2,3,4-tetrakisphosphate | purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+ | Rattus norvegicus | |
D-scyllo-inositol 1,2,4-trisphosphate | purified recombinant enzyme, IC50 value is 0.044 mM in absence of Ca2+ | Rattus norvegicus | |
L-scyllo-inositol 1,2,3,4-tetrakisphosphate | purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+ | Rattus norvegicus | |
L-scyllo-inositol 1,2,4-trisphosphate | purified recombinant enzyme, IC50 value is 0.006 mM in absence of Ca2+ | Rattus norvegicus | |
additional information | inhibitor binding structures and mechanism, scyllo-inositol pentakisphosphate, scyllo-inositol hexakisphosphate, scyllo-inositol monophosphate, and scyllo-inositol S-bisphosphates are poor inhibitors | Rattus norvegicus | |
scyllo-inositol 1,2,3,5-tetrakisphosphate | weak inhibition, purified recombinant enzyme, IC50 value is 0.028 mM in absence of Ca2+ | Rattus norvegicus | |
scyllo-inositol 1,2,3-trisphosphate | purified recombinant enzyme, IC50 value is 0.027 mM in absence of Ca2+ | Rattus norvegicus | |
scyllo-inositol 1,2,4,5-tetrakisphosphate | weak inhibition, purified recombinant enzyme, IC50 value is 0.039 mM in absence of Ca2+ | Rattus norvegicus | |
scyllo-inositol 1,3,5-trisphosphate | purified recombinant enzyme, IC50 value is 0.090 mM in absence of Ca2+ | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Rattus norvegicus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
inositol 1,4,5-trisphosphate 3-kinase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.003 | - |
strong inhibition, purified recombinant enzyme, IC50 value is 0.003 mM in absence of Ca2+ | Rattus norvegicus | D-myo-inositol 1,4,5-trisphosphate | |
0.006 | - |
purified recombinant enzyme, IC50 value is 0.006 mM in absence of Ca2+ | Rattus norvegicus | L-scyllo-inositol 1,2,4-trisphosphate | |
0.027 | - |
purified recombinant enzyme, IC50 value is 0.027 mM in absence of Ca2+ | Rattus norvegicus | scyllo-inositol 1,2,3-trisphosphate | |
0.028 | - |
weak inhibition, purified recombinant enzyme, IC50 value is 0.028 mM in absence of Ca2+ | Rattus norvegicus | scyllo-inositol 1,2,3,5-tetrakisphosphate | |
0.039 | - |
weak inhibition, purified recombinant enzyme, IC50 value is 0.039 mM in absence of Ca2+ | Rattus norvegicus | scyllo-inositol 1,2,4,5-tetrakisphosphate | |
0.044 | - |
purified recombinant enzyme, IC50 value is 0.044 mM in absence of Ca2+ | Rattus norvegicus | D-scyllo-inositol 1,2,4-trisphosphate | |
0.09 | - |
purified recombinant enzyme, IC50 value is 0.090 mM in absence of Ca2+ | Rattus norvegicus | scyllo-inositol 1,3,5-trisphosphate | |
0.1 | - |
purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+ | Rattus norvegicus | D-scyllo-inositol 1,2,3,4-tetrakisphosphate | |
0.1 | - |
purified recombinant enzyme, IC50 value is above 0.1 mM in absence of Ca2+ | Rattus norvegicus | L-scyllo-inositol 1,2,3,4-tetrakisphosphate |