Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cholesterol | DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such cholesterol | Homo sapiens | |
cholesterol | DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such cholesterol | Mus musculus | |
P53 | p53 activates DGKalpha in response to DNA damage | Homo sapiens | |
P53 | p53 activates DGKalpha in response to DNA damage | Mus musculus | |
phosphatidylethanolamine | DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such as phosphatidylethanolamine | Homo sapiens | |
phosphatidylethanolamine | DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such as phosphatidylethanolamine | Mus musculus |
General Stability | Organism |
---|---|
activation of tyrosine kinases is required for membrane stabilization of DGKalpha, phosphorylation of DGKalpha at Tyr335 appears to be essential for membrane localization | Homo sapiens |
activation of tyrosine kinases is required for membrane stabilization of DGKalpha, phosphorylation of DGKalpha at Tyr335 appears to be essential for membrane localization | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function | Homo sapiens | 5829 | - |
cytosol | DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function | Mus musculus | 5829 | - |
membrane | DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function | Homo sapiens | 16020 | - |
membrane | DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function | Mus musculus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Ca2+ requirement in DGKalpha activation | Homo sapiens | |
Ca2+ | Ca2+ requirement in DGKalpha activation | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P23743 | - |
- |
Mus musculus | O88673 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | high expression | Mus musculus | - |
endothelial cell | - |
Homo sapiens | - |
endothelial cell | - |
Mus musculus | - |
heart | low expression | Mus musculus | - |
kidney | low expression | Mus musculus | - |
liver | low expression | Mus musculus | - |
lung | high expression | Mus musculus | - |
oligodendrocyte | DGKalpha is expressed predominantly in oligodendrocytes | Homo sapiens | - |
oligodendrocyte | DGKalpha is expressed predominantly in oligodendrocytes | Mus musculus | - |
spleen | high expression | Mus musculus | - |
T-lymphocyte | particularly enriched in peripheral T lymphocytes | Homo sapiens | - |
T-lymphocyte | particularly enriched in peripheral T lymphocytes | Mus musculus | - |
testis | high expression | Mus musculus | - |
thymus | particularly enriched in thymus | Homo sapiens | - |
thymus | particularly enriched in thymus | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacylglycerol | - |
Homo sapiens | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1,2-diacylglycerol | - |
Mus musculus | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGKalpha | isoform | Homo sapiens |
DGKalpha | isoform | Mus musculus |
diacylglycerol kinase alpha | isoform | Homo sapiens |
diacylglycerol kinase alpha | isoform | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | p53-mediated upregulation of DGKalpha mRNA in human-derived cells, (PPAR)-gamma-dependent DGKalpha upregulation in endothelial cells, DMSO-based differentiation of promyelocytic HL-60 cells into a neutrophilic phenotype correlates with increase in the expression of DGKalpha, DGKalpha expression is upregulated in cancer | up |
Mus musculus | p53-mediated upregulation of DGKalpha mRNA in mouse-derived cells, (PPAR)-gamma-dependent DGKalpha upregulation in endothelial cells, DMSO-based differentiation of promyelocytic HL-60 cells into a neutrophilic phenotype correlates with increase in the expression of DGKalpha, DGKalpha expression is upregulated in cancer | up |
General Information | Comment | Organism |
---|---|---|
physiological function | membrane localization of DGKalpha acts as a switch-off signal for Ras activation, mediated by localization to the membrane of Ras-GRP1, DGKalpha is a negative regulator of the T cell activation program, DGKalpha activity is required for optimal chemotactic response of neutrophils, whereas it halts their oxidative burst, DGKalpha is a negative modulator of diacylglycerol signaling, DGKalpha activity modulates the mTOR pathway to prevent cell cycle transition, DGKalpha is an indicator of cell quiescence, DGKalpha is a positive regulator of cell proliferation and migration | Homo sapiens |
physiological function | membrane localization of DGKalpha acts as a switch-off signal for Ras activation, mediated by localization to the membrane of Ras-GRP1, DGKalpha is a negative regulator of the T cell activation program, DGKalpha activity is required for optimal chemotactic response of neutrophils, whereas it halts their oxidative burst, DGKalpha is a negative modulator of diacylglycerol signaling, DGKalpha activity modulates the mTOR pathway to prevent cell cycle transition, DGKalpha is an indicator of cell quiescence, DGKalpha is a positive regulator of cell proliferation and migration | Mus musculus |