Application | Comment | Organism |
---|---|---|
medicine | diacylglycerol kinase delta haploinsufficiency increases diacylglycerol content, reduces peripheral insulin sensitivity, insulin signaling, and glucose transport, and leads to age-dependent obesity. Metabolic flexibility is impaired | Mus musculus |
medicine | patients with type 2 diabetes mellitus display reduced diacylglycerol kinase delta expression and activity in skeletal muscle | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of heterozygous diacylglycerol kinase delta whole-body knockout mice. Diacylglycerol kinase delta haploinsufficiency increases diacylglycerol content, reduces peripheral insulin sensitivity, insulin signaling, and glucose transport, and leads to age-dependent obesity. Metabolic flexibility is impaired | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
R59022 | decrease in total diacylglycerol kinase activity and increases in diacylglycerol levels upon incubation of skeletal muscle, with parallel increase in protein kinase C activity and isoform-specific phosphorylation of protein kinase Cdelta. Diacylglycerol kinase inhibition also reduces insulin-stimulated glucose transport | Rattus norvegicus | |
R59949 | decrease in total diacylglycerol kinase activity and increases in diacylglycerol levels upon incubation of skeletal muscle, with parallel increase in protein kinase C activity and isoform-specific phosphorylation of protein kinase Cdelta. Diacylglycerol kinase inhibition also reduces insulin-stimulated glucose transport | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | mainly associated with internal membranes | Rattus norvegicus | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16760 | - |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle | epitrochlearis muscle | Mus musculus | - |
skeletal muscle | epitrochlearis muscle | Rattus norvegicus | - |
skeletal muscle | patients with type 2 diabetes mellitus display reduced diacylglycerol kinase delta expression and activity in skeletal muscle | Homo sapiens | - |