Literature summary for 2.7.1.107 extracted from

Bilim, O.; Takeishi, Y.; Kitahara, T.; Arimoto, T.; Niizeki, T.; Sasaki, T.; Goto, K.; Kubota, I.
Diacylglycerol kinase zeta inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus (2008), Cardiovasc. Diabetol., 7, 2.

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Application

Application	Comment	Organism
medicine	comparison of transgenic mice with cardiac-specific overexpression of diacylglycerol kinase zeta and wild-type mice in streptozotocin-induced diabetic and non-diabetic conditions. After 8 weeks, decreases in heart weight and heart weight/body weight ratio in diabetic wild-type mice are inhibited in transgenic mice. Decreases in left ventricular end-diastolic diameter and fractional shortening observed in wild-type mice are attenuated in transgenic mice. Thinning of the interventricular septum and the posterior wall in diabetic wild-type hearts are blocked in transgenic mice. Reduction of transverse diameter of cardiomyocytes isolated from the left ventricle in diabetic wild-type mice is attenuated in transgenic mice. Cardiac fibrosis was much less in diabetic transgenic than in diabetic wild-type mice	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q80UP3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Mus musculus	-

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Release 2023.1 (January 2023)