Cloned (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
- |
Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
citrate | - |
Bos taurus | |
citrate | - |
Rattus norvegicus | |
additional information | - |
Bos taurus | |
additional information | the islet enzyme lacks protein kinase A and C phosphorylation sites | Rattus norvegicus | |
phosphoenolpyruvate | - |
Bos taurus | |
phosphoenolpyruvate | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.016 | - |
beta-D-fructose 6-phosphate | pH 7.5, 25°C, liver | Rattus norvegicus | |
0.017 | - |
beta-D-fructose 6-phosphate | pH 7.5, 25°C, islet | Rattus norvegicus | |
0.023 | - |
beta-D-fructose 6-phosphate | pH 7.5, 25°C, heart | Bos taurus | |
0.04 | - |
beta-D-fructose 6-phosphate | pH 7.5, 25°C, testis | Rattus norvegicus | |
0.048 | - |
ATP | pH 7.5, 25°C, heart | Rattus norvegicus | |
0.056 | - |
beta-D-fructose 6-phosphate | pH 7.5, 25°C, muscle | Rattus norvegicus | |
0.083 | - |
ATP | pH 7.5, 25°C, heart | Bos taurus | |
0.1 | - |
ATP | - |
Bos taurus | |
0.1 | - |
ATP | pH 7.5, 25°C, testis | Rattus norvegicus | |
0.31 | - |
ATP | pH 7.5, 25°C, liver | Rattus norvegicus | |
0.328 | - |
ATP | pH 7.5, 25°C, islet | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-D-fructose 6-phosphate | Rattus norvegicus | responsible for regulation of fructose 2,6-bisphosphate-concentration | ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
ATP + beta-D-fructose 6-phosphate | Bos taurus | responsible for regulation of fructose 2,6-bisphosphate-concentration | ADP + beta-D-fructose 2,6-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Bos taurus |
phosphoprotein | the islet enzyme lacks protein kinase A and C phosphorylation sites | Rattus norvegicus |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Rattus norvegicus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate | bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 | Rattus norvegicus | |
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate | bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 | Bos taurus | |
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate | high 6-phosphofructo-2-kinase activity compared to the fructose 2,6-bisphosphatase | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Rattus norvegicus | - |
heart | - |
Bos taurus | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Bos taurus | - |
pancreatic islet | - |
Rattus norvegicus | - |
skeletal muscle | - |
Rattus norvegicus | - |
testis | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-D-fructose 6-phosphate | - |
Rattus norvegicus | ADP + beta-D-fructose 2,6-bisphosphate | - |
r | |
ATP + beta-D-fructose 6-phosphate | - |
Bos taurus | ADP + beta-D-fructose 2,6-bisphosphate | - |
r | |
ATP + beta-D-fructose 6-phosphate | responsible for regulation of fructose 2,6-bisphosphate-concentration | Rattus norvegicus | ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
ATP + beta-D-fructose 6-phosphate | responsible for regulation of fructose 2,6-bisphosphate-concentration | Bos taurus | ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
additional information | also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) | Rattus norvegicus | ? | - |
? | |
additional information | also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) | Bos taurus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Rattus norvegicus |
25 | - |
assay at | Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.08 | - |
phosphoenolpyruvate | pH 7.5, 25°C, islet | Rattus norvegicus |