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Literature summary for 2.7.1.105 extracted from

  • El-Maghrabi, M.R.; Correia, J.J.; Heil, P.J.; Pate, T.M.; Cobb, C.E.; Pilkis, S.J.
    Tissue distribution, immunoreactivity, and physical properties of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (1986), Proc. Natl. Acad. Sci. USA, 83, 5005-5009.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
iodoacetamide activation, kidney and liver, not heart or testis enzyme Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Bos taurus
additional information phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme, not of kidney, testis and heart enzyme Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus
Mg2+
-
Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
2 * 55000, SDS-PAGE Rattus norvegicus
107000 109000 equilibrium sedimentation, sedimentation velocity analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-D-fructose 6-phosphate Bos taurus
-
ADP + beta-D-fructose 2,6-bisphosphate
-
?
ATP + beta-D-fructose 6-phosphate Rattus norvegicus enzyme plays an important role in the regulation of hepatic carbohydrate metabolism ADP + beta-D-fructose 2,6-bisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Canis lupus familiaris
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme, not of kidney, testis and heart enzyme Rattus norvegicus
phosphoprotein phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Rattus norvegicus
phosphoprotein phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Bos taurus

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Rattus norvegicus
-
heart
-
Bos taurus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
liver
-
Bos taurus
-
liver
-
Canis lupus familiaris
-
lung
-
Rattus norvegicus
-
additional information tissue distribution, in extrahepatic tissue only 10% or less of activity in liver Rattus norvegicus
-
skeletal muscle
-
Rattus norvegicus
-
testis
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-fructose 6-phosphate
-
Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
?
ATP + beta-D-fructose 6-phosphate
-
Bos taurus ADP + beta-D-fructose 2,6-bisphosphate
-
?
ATP + beta-D-fructose 6-phosphate
-
Canis lupus familiaris ADP + beta-D-fructose 2,6-bisphosphate
-
?
ATP + beta-D-fructose 6-phosphate enzyme plays an important role in the regulation of hepatic carbohydrate metabolism Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
?
additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Rattus norvegicus ?
-
?
additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Bos taurus ?
-
?
additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Canis lupus familiaris ?
-
?
additional information allosteric bifunctional enzyme, not heart Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
dimer
-
Bos taurus
dimer
-
Canis lupus familiaris
dimer 2 * 55000, SDS-PAGE Rattus norvegicus