Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
acrosome | tPFK-2 | Rattus norvegicus | - |
- |
flagellum | tPFK-2 | Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley rat | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
interstitial cell | uPFK-2 | Rattus norvegicus | - |
Sertoli cell | uPFK-2 | Rattus norvegicus | - |
sperm flagellum | - |
Rattus norvegicus | - |
spermatocyte | uPFK-2, tPFK-2 | Rattus norvegicus | - |
testis | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
6-phosphofructo-2-kinase | - |
Rattus norvegicus |
PFKFB3 | - |
Rattus norvegicus |
PFKFB3 | gene name of isoform | Rattus norvegicus |
PFKFB4 | - |
Rattus norvegicus |
PFKFB4 | gene name of isoform | Rattus norvegicus |
tPFK-2 | isoform, product of Pfkfb4 gene | Rattus norvegicus |
uPFK-2 | isoform, product of Pfkfb3 gene | Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | maximum expression of Pfkfb3 in cells before puberty, maximum expression of Pfkfb4 in adult cells | up |
General Information | Comment | Organism |
---|---|---|
metabolism | glycolytic enzyme is present as testis-specific isoforms, these isoforms are expressed specifically or predominantly in spermatogenic cells, often during the post-meiotic phase, and replace the ubiquitous isozymes that are also present in somatic cells | Rattus norvegicus |
physiological function | spermatogenesis, both PFK-2 isozymes have specific roles in testis metabolism and physiology, PFK-2 isozyme expression switches from the ubiquitous form, required during proliferative phases, to the testicular form, which is the germ cell-specific one | Rattus norvegicus |