Literature summary for 2.7.1.105 extracted from

Kim, S.G.; Manes, N.P.; El-Maghrabi, M.R.; Lee, Y.H.
Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy (2006), J. Biol. Chem., 281, 2939-2944.

Search for more literature for 2.7.1.105

Application

Application	Comment	Organism
medicine	a molecule in which EDTA is covalently linked to ADP is a good starting molecule for the development of new cancer-therapeutic molecules	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
His-tagged enzyme recombinantly expressed in Escherichia coli, sitting drop vapor diffusion method	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + beta-D-fructose 6-phosphate	Homo sapiens	PFKFB3 plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways even under severe hypoxic conditions	ADP + beta-D-fructose 2,6-bisphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16118	recombinant	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + beta-D-fructose 6-phosphate	PFKFB3 plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways even under severe hypoxic conditions	Homo sapiens	ADP + beta-D-fructose 2,6-bisphosphate	-	?

Synonyms

Synonyms	Comment	Organism
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase	-	Homo sapiens
PFKFB3	-	Homo sapiens

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Release 2023.1 (January 2023)