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Literature summary for 2.7.1.1 extracted from

  • Bryan, N.; Raisch, K.
    Identification of a mitochondrial-binding site on the N-terminal end of hexokinase II (2015), Biosci. Rep., 35, e00205.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.1

Application

Application Comment Organism
medicine hexokinase-II binds to the voltage-dependent anion channel located on the mitochondrial outer membrane. When bound, hexokinase-II is blocking a major cell death pathway. A series of truncations and point mutations to the N-terminal end of hexokinase-II identify the binding site to the channel within the first 10 amino acids Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
transfection of U-2OS cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
A8L mutant maintains binding to mitochondrial-like membrane structures Homo sapiens
H5P mutation abolishes binding to mitochondrial-like membrane structures, and a greater than 4fold decrease in H5P protein levels as compared with wild-type protein levels is found in the cytoplasmic fraction Homo sapiens
additional information hexokinase-II binds to the voltage-dependent anion channel located on the mitochondrial outer membrane. When bound, hexokinase-II is blocking a major cell death pathway. A series of truncations and point mutations to the N-terminal end of hexokinase-II identify the binding site to the channel within the first 10 amino acids Homo sapiens
S4L mutant maintains binding to mitochondrial-like membrane structures, a greater than 6fold increase in S4L mutant protein is found in the mitochondrial fraction Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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