Literature summary for 2.7.1.1 extracted from

Zhuo, B.; Li, Y.; Li, Z.; Qin, H.; Sun, Q.; Zhang, F.; Shen, Y.; Shi, Y.; Wang, R.
PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma (2015), Biochem. Biophys. Res. Commun., 464, 401-406.

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Application

Application	Comment	Organism
medicine	in cancer cells, elevated hexokinase-2 expression is induced by activated PI3K/Akt signaling. Hexokinase-2 is overexpressed in 83.3% of specimens detected and is closely correlated with Ki67, a cell proliferation index. Silencing of endogenous hexokinase-2 results in decreased aerobic glycolysis. Inhibition of PI3K/Akt signaling also suppresses aerobic glycolysis and this effect can be reversed by reintroduction of hexokinase-2. Knockdown of HK2 leads to increased cell apoptosis and reduced ability of colony formation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HOS cell	-	Homo sapiens	-
KHOS cell	-	Homo sapiens	-
KRIB cell	-	Homo sapiens	-
MG-63 cell	-	Homo sapiens	-
SAOS-2 cell	-	Homo sapiens	-
U2-OS cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)