Literature summary for 2.7.1.1 extracted from

Fichera, G.A.; Fichera, M.; Milone, G.
Antitumoural activity of a cytotoxic peptide of Lactobacillus casei peptidoglycan and its interaction with mitochondrial-bound hexokinase (2016), Anticancer Drugs, 27, 609-619.

Search for more literature for 2.7.1.1

Application

Application	Comment	Organism
medicine	the peptidoglycan of Lactobacillus casei shows cytotoxic activity against various tumour cells. A synthetic peptide derived from the peptidoglycan impairs the entire metabolism of cultured tumour cells and restores the apoptotic process. Normal cells appear to be stimulated rather than inhibited by the peptide. The pentapeptide binds with the hexokinase and exerts a weak inhibitory effect on hexokinase enzymatic specific activity. in tumour cells, a percentage of peptide is partially blocked by the cytosolic hexokinase and the remaining is available to bind with the mitochondrial-bound hexokinase. This binding triggers the Bax-induced proapoptotic process including a decrease in succinate dehydrogenase activity, cellular ATP and mitochondrial membrane potential, as well as changes in the voltage dependent anion channel structure on the outer mitochondrial membrane and cytochrome C release. As the final stage, the antiapoptotic process is suppressed, the cellular functions are altered and the cell is destroyed	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Ehrlich ascites carcinoma cell	-	Mus musculus	-
MMT-060562 cell	mouse mammary tumour cell	Mus musculus	-
Neuro-2a cell	-	Mus musculus	-
P-815 cell	-	Mus musculus	-
YAC-1 cell	mouse lymphoma cell	Mus musculus	-

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Release 2023.1 (January 2023)