Literature summary for 2.7.1.1 extracted from

Lin, X.W.; Xu, W.H.
Hexokinase is a key regulator of energy metabolism and ROS activity in insect lifespan extension (2016), Aging, 8, 245-259.

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Organism

Organism	UniProt	Comment	Textmining
Helicoverpa armigera	A0A0P0I1H5	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pupa	expression and activity levels are significantly increased in nondiapause-destined pupae compared with those of diapause-destined pupae	Helicoverpa armigera	-

General Information

General Information	Comment	Organism
physiological function	downregulation of activity reduces cell viability and delays pupaldevelopment by reducing metabolic activity and increasing reactive oxygen species activity. The transcription factors CREB, c-Myc, and POU are specifically binding the hexokinase gene promoter and regulating its activity. POU and c-Myc are specific transcription factors for hexokinase expression, whereas CREB is nonspecific. Low ecdysone levels in diapause-destined individuals lead to low POU and c-Myc expression levels, ultimately repressing hexokinase expression and inducing entry into diapause or lifespan extension	Helicoverpa armigera

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Release 2023.1 (January 2023)