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Literature summary for 2.7.1.1 extracted from

  • Beer, N.L.; Tribble, N.D.; McCulloch, L.J.; Roos, C.; Johnson, P.R.; Orho-Melander, M.; Gloyn, A.L.
    The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver (2009), Hum. Mol. Genet., 18, 4081-4088.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.1

Inhibitors

Inhibitors Comment Organism Structure
glucokinase regulatory protein competitive inhibitor of GCK activity, fructose 6-phoshate and fructose 1-phosphate enhance or reduce glucokinase regulatory protein-mediated inhibition, respectively. P446L-glucokinase regulatory protein has reduced regulation by physiological concentrations of fructose 6-phoshate, resulting indirectly in increased glucokinase activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte very low expression Homo sapiens
-
liver
-
 Homo sapiens
-
additional information not expressed in skeletal muscle and kidney Homo sapiens
-
pancreas
-
 Homo sapiens
-
pancreatic islet highest expression in islet cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-glucose
-
 Homo sapiens ADP + D-glucose 6-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
GCK
-
 Homo sapiens
glucokinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function glucokinase regulates glucose storage and disposal in the liver, altered glucokinase regulation in liver enhances glycolytic flux, promoting hepatic glucose metabolism and elevating concentrations of malonyl-CoA, a substrate for de novo lipogenesis Homo sapiens