Activating Compound | Comment | Organism | Structure |
---|---|---|---|
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Mus musculus | |
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Homo sapiens | |
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Rattus norvegicus | |
glucokinase-associated protein | stimulates glucokinase activity by 30-40% when present at a 3-5fold molar excess and 2.5fold at a 50fold molar excess | Mus musculus | |
glucokinase-associated protein | stimulates glucokinase activity by 30-40% when present at a 3-5fold molar excess and 2.5fold at a 50fold molar excess | Homo sapiens | |
glucokinase-associated protein | stimulates glucokinase activity by 30-40% when present at a 3-5fold molar excess and 2.5fold at a 50fold molar excess | Rattus norvegicus | |
polyubiquitin | causes modest activation | Mus musculus | |
polyubiquitin | causes modest activation | Homo sapiens | |
polyubiquitin | causes modest activation | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glucokinase regulatory protein | competitive inhibitor of glucokinase, in the fasted state, glucokinase is in part sequestered in the nucleus in an inactive state, complexed to a specific regulatory protein, glucokinase regulatory protein | Homo sapiens | |
glucokinase regulatory protein | competitive inhibitor of glucokinase, in the fasted state, glucokinase is in part sequestered in the nucleus in an inactive state, complexed to a specific regulatory protein, glucokinase regulatory protein | Mus musculus | |
glucokinase regulatory protein | competitive inhibitor of glucokinase, in the fasted state, glucokinase is in part sequestered in the nucleus in an inactive state, complexed to a specific regulatory protein, glucokinase regulatory protein | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | free glucokinase is localized in the cytosol | Mus musculus | 5829 | - |
cytosol | free glucokinase is localized in the cytosol | Homo sapiens | 5829 | - |
cytosol | free glucokinase is localized in the cytosol | Rattus norvegicus | 5829 | - |
nucleus | glucokinase regulatory protein causes accumulation of glucokinase in the nucleus | Mus musculus | 5634 | - |
nucleus | glucokinase regulatory protein causes accumulation of glucokinase in the nucleus | Homo sapiens | 5634 | - |
nucleus | glucokinase regulatory protein causes accumulation of glucokinase in the nucleus | Rattus norvegicus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required for activity | Mus musculus | |
Mg2+ | required for activity | Homo sapiens | |
Mg2+ | required for activity | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-glucose | - |
Mus musculus | ADP + D-glucose 6-phosphate | - |
? | |
ATP + D-glucose | - |
Homo sapiens | ADP + D-glucose 6-phosphate | - |
? | |
ATP + D-glucose | - |
Rattus norvegicus | ADP + D-glucose 6-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glucokinase | - |
Mus musculus |
glucokinase | - |
Homo sapiens |
glucokinase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | defect in the activation of glucokinase is potential contributing factor to the dysregulation of hepatic glucose metabolism in type 2 diabetes | Mus musculus |
malfunction | defect in the activation of glucokinase is potential contributing factor to the dysregulation of hepatic glucose metabolism in type 2 diabetes | Homo sapiens |
malfunction | defect in the activation of glucokinase is potential contributing factor to the dysregulation of hepatic glucose metabolism in type 2 diabetes | Rattus norvegicus |