Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2-pyridin-4-ylethane-1,1-diyl)bis(phosphonic acid) | mixed to non-competitive inhibitors against ATP, non-competitive against D-glucose | Trypanosoma cruzi | |
(3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate | - |
Trypanosoma cruzi | |
(9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisphosphonate | - |
Trypanosoma cruzi | |
2-(pyridin-4-yl)-1-hydroxyethane-1,1-bisphosphonate | - |
Trypanosoma cruzi | |
diphosphate | non-competitive inhibition towards ATP, mixed-type towards D-glucose; non-competitive inhibitor | Trypanosoma cruzi | |
additional information | enzyme is not affected by D-glucose 6-phosphate; TcHK is not affected by D-glucose 6-phosphate | Trypanosoma cruzi | |
[[(3-bromophenyl)amino]methylene]bis(phosphonic acid) | mixed to non-competitive inhibitors against ATP, competitive against D-glucose | Trypanosoma cruzi | |
[[(9-ethyl-9H-carbazol-3-yl)amino]methylene]bis(phosphonic acid) | mixed to non-competitive inhibitors against ATP, competitive against D-glucose | Trypanosoma cruzi |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.03 | - |
ATP | - |
Trypanosoma cruzi | |
0.463 | - |
D-glucose | - |
Trypanosoma cruzi |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
glycosome | - |
Trypanosoma cruzi | 20015 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Trypanosoma cruzi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-glucose | - |
Trypanosoma cruzi | ADP + D-glucose 6-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATP-dependent hexokinase | - |
Trypanosoma cruzi |
TcHK | - |
Trypanosoma cruzi |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0004 | - |
(3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate | varied substrate is D-glucose, in the presence of 1 mM ATP and 3 mM MgCl2, Kis | Trypanosoma cruzi | |
0.0005 | - |
(9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisphosphonate | varied substrate is D-glucose, in the presence of 1 mM ATP and 3 mM MgCl2, Kis | Trypanosoma cruzi | |
0.0006 | - |
(3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate | varied substrate is ATP, in the presence of 2 mM D-glucose and 3 mM MgCl2, Kis | Trypanosoma cruzi | |
0.0012 | - |
(3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate | varied substrate is ATP, in the presence of 2 mM D-glucose and 3 mM MgCl2, Kii | Trypanosoma cruzi | |
0.0017 | - |
(9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisphosphonate | varied substrate is ATP, in the presence of 2 mM D-glucose and 3 mM MgCl2, Kis | Trypanosoma cruzi | |
0.0028 | - |
(9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisphosphonate | varied substrate is ATP, in the presence of 2 mM D-glucose and 3 mM MgCl2, Kii | Trypanosoma cruzi | |
0.0028 | - |
2-(pyridin-4-yl)-1-hydroxyethane-1,1-bisphosphonate | varied substrate is ATP, in the presence of 2 mM D-glucose and 3 mM MgCl2, Kis | Trypanosoma cruzi | |
0.0033 | - |
2-(pyridin-4-yl)-1-hydroxyethane-1,1-bisphosphonate | varied substrate is D-glucose, in the presence of 1 mM ATP and 3 mM MgCl2, Kis | Trypanosoma cruzi | |
0.0043 | - |
2-(pyridin-4-yl)-1-hydroxyethane-1,1-bisphosphonate | varied substrate is ATP, in the presence of 2 mM D-glucose and 3 mM MgCl2, Kii | Trypanosoma cruzi | |
0.006 | - |
2-(pyridin-4-yl)-1-hydroxyethane-1,1-bisphosphonate | varied substrate is D-glucose, in the presence of 1 mM ATP and 3 mM MgCl2, Kii | Trypanosoma cruzi | |
22 | 83 | [[(9-ethyl-9H-carbazol-3-yl)amino]methylene]bis(phosphonic acid) | against ATP, Kii | Trypanosoma cruzi | |
32.8 | - |
(2-pyridin-4-ylethane-1,1-diyl)bis(phosphonic acid) | against ATP, Kis | Trypanosoma cruzi | |
33.3 | - |
(2-pyridin-4-ylethane-1,1-diyl)bis(phosphonic acid) | against D-glucose, Kis | Trypanosoma cruzi | |
34.3 | - |
(2-pyridin-4-ylethane-1,1-diyl)bis(phosphonic acid) | Kii | Trypanosoma cruzi | |
36 | - |
(2-pyridin-4-ylethane-1,1-diyl)bis(phosphonic acid) | against D-glucose, Kii | Trypanosoma cruzi | |
2281 | - |
[[(9-ethyl-9H-carbazol-3-yl)amino]methylene]bis(phosphonic acid) | against D-glucose, Kis | Trypanosoma cruzi | |
2282 | - |
[[(9-ethyl-9H-carbazol-3-yl)amino]methylene]bis(phosphonic acid) | against ATP, Kis | Trypanosoma cruzi | |
3020 | - |
[[(3-bromophenyl)amino]methylene]bis(phosphonic acid) | against D-glucose, Kis | Trypanosoma cruzi | |
3021 | - |
[[(3-bromophenyl)amino]methylene]bis(phosphonic acid) | against ATP, Kii | Trypanosoma cruzi | |
3021 | - |
[[(3-bromophenyl)amino]methylene]bis(phosphonic acid) | against ATP, Kis | Trypanosoma cruzi |