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Literature summary for 2.7.1.1 extracted from

  • Sener, A.; Malaisse, W.J.
    Kinetics and specificity of human B-cell glucokinase: relevance to hexose-induced insulin release (1996), Biochim. Biophys. Acta, 1312, 73-78.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
D-glucose 6-phosphate noncompetitive inhibition Homo sapiens
D-mannoheptulose competitive inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.8
-
D-glucose 30°C, pH 7.5 Homo sapiens
4.6
-
D-mannose 30°C, pH 7.5 Homo sapiens
157.7
-
D-fructose 30°C, pH 7.5 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-glucose Homo sapiens
-
ADP + D-glucose 6-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
B-cells
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell
-
Homo sapiens
-
pancreatic islet
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
35.7
-
D-mannose as substrate Homo sapiens
38.1
-
D-glucose as substrate Homo sapiens
98.7
-
D-fructose as substrate Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2-deoxy-D-glucose
-
Homo sapiens ADP + 2-deoxy-D-glucose 6-phosphate
-
?
ATP + D-fructose
-
Homo sapiens ADP + D-fructose 6-phosphate
-
?
ATP + D-glucose
-
Homo sapiens ADP + D-glucose 6-phosphate
-
?
ATP + D-mannose
-
Homo sapiens ADP + D-mannose 6-phosphate
-
?