Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Trypanosoma cruzi | |
D-glucose 6-phosphate | - |
Trypanosoma cruzi |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Trypanosoma cruzi | |
0.85 | - |
D-mannose | - |
Trypanosoma cruzi | |
1 | - |
D-fructose | - |
Trypanosoma cruzi |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | absolute requirement for Mg2+ and ATP | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
hexokinase I | - |
Purification (Comment) | Organism |
---|---|
hexokinase I, 103fold | Trypanosoma cruzi |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epimastigote | - |
Trypanosoma cruzi | - |
Storage Stability | Organism |
---|---|
at least 3 months, stable | Trypanosoma cruzi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-fructose + ATP | - |
Trypanosoma cruzi | ADP + D-fructose 6-phosphate | - |
? | |
D-glucose + ATP | most active with D-glucose | Trypanosoma cruzi | ADP + D-glucose 6-phosphate | - |
? | |
D-mannose + ATP | - |
Trypanosoma cruzi | ADP + D-mannose 6-phosphate | - |
? | |
GTP + D-glucose | can partially replace ATP | Trypanosoma cruzi | GDP + D-glucose 6-phosphate | - |
? | |
UTP + D-glucose | can partially replace ATP | Trypanosoma cruzi | UDP + D-glucose 6-phosphate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Trypanosoma cruzi |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
optimal activity at pH 6.5 and 9.0 at 37°C | Trypanosoma cruzi |
9 | - |
optimal activity at pH 6.5 and 9.0 at 37°C | Trypanosoma cruzi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | absolute requirement for Mg2+ and ATP | Trypanosoma cruzi |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.13 | - |
ADP | - |
Trypanosoma cruzi | |
1.4 | - |
D-glucose 6-phosphate | - |
Trypanosoma cruzi |