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Literature summary for 2.7.1.1 extracted from
- Purification and properties of hexokinase from Trypanosoma cruzi (1980), Arq. Biol. Tecnol. (Curitiba), 23, 283-294.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Trypanosoma cruzi |  |
| D-glucose 6-phosphate | - |
Trypanosoma cruzi | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Trypanosoma cruzi | |
| 0.85 | - |
D-mannose | - |
Trypanosoma cruzi | |
| 1 | - |
D-fructose | - |
Trypanosoma cruzi | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | absolute requirement for Mg2+ and ATP | Trypanosoma cruzi | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma cruzi | - |
hexokinase I | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| hexokinase I, 103fold | Trypanosoma cruzi |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epimastigote | - |
Trypanosoma cruzi | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| at least 3 months, stable | Trypanosoma cruzi |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-fructose + ATP | - |
Trypanosoma cruzi | ADP + D-fructose 6-phosphate | - |
? | |
| D-glucose + ATP | most active with D-glucose | Trypanosoma cruzi | ADP + D-glucose 6-phosphate | - |
? | |
| D-mannose + ATP | - |
Trypanosoma cruzi | ADP + D-mannose 6-phosphate | - |
? | |
| GTP + D-glucose | can partially replace ATP | Trypanosoma cruzi | GDP + D-glucose 6-phosphate | - |
? | |
| UTP + D-glucose | can partially replace ATP | Trypanosoma cruzi | UDP + D-glucose 6-phosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Trypanosoma cruzi |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
optimal activity at pH 6.5 and 9.0 at 37°C | Trypanosoma cruzi |
| 9 | - |
optimal activity at pH 6.5 and 9.0 at 37°C | Trypanosoma cruzi |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | absolute requirement for Mg2+ and ATP | Trypanosoma cruzi | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.13 | - |
ADP | - |
Trypanosoma cruzi | |
| 1.4 | - |
D-glucose 6-phosphate | - |
Trypanosoma cruzi | |
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