Application | Comment | Organism |
---|---|---|
pharmacology | the enzyme is a target for drug development in the treatment of human pathogens being capable, in contrast to the hosts, to synthesize pyridoxine 5'-phosphate | Salmonella enterica subsp. enterica serovar Typhimurium |
pharmacology | the enzyme is a target for drug development in the treatment of human pathogens being capable, in contrast to the hosts, to synthesize pyridoxine 5'-phosphate | Escherichia coli |
pharmacology | the enzyme is a target for drug development in the treatment of human pathogens being capable, in contrast to the hosts, to synthesize pyridoxine 5'-phosphate | Neisseria gonorrhoeae |
pharmacology | the enzyme is a target for drug development in the treatment of human pathogens being capable, in contrast to the hosts, to synthesize pyridoxine 5'-phosphate | Neisseria meningitidis |
pharmacology | the enzyme is a target for drug development in the treatment of human pathogens being capable, in contrast to the hosts, to synthesize pyridoxine 5'-phosphate | Yersinia pestis |
pharmacology | the enzyme is a target for drug development in the treatment of human pathogens being capable, in contrast to the hosts, to synthesize pyridoxine 5'-phosphate | Salmonella enterica subsp. enterica serovar Typhi |
pharmacology | the enzyme is a target for drug development in the treatment of human pathogens being capable, in contrast to the hosts, to synthesize pyridoxine 5'-phosphate | Vibrio cholerae serotype O1 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | Salmonella enterica subsp. enterica serovar Typhimurium | involved in the de novo synthesis of vitamin B6 | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | Neisseria gonorrhoeae | involved in the de novo synthesis of vitamin B6 | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | Neisseria meningitidis | involved in the de novo synthesis of vitamin B6 | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | Yersinia pestis | involved in the de novo synthesis of vitamin B6 | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | Salmonella enterica subsp. enterica serovar Typhi | involved in the de novo synthesis of vitamin B6 | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | Vibrio cholerae serotype O1 | involved in the de novo synthesis of vitamin B6 | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | Escherichia coli | key enzyme in the group of pdx gene-encoded enzymes involved in the de novo synthesis of vitamin B6 | pyridoxine 5'-phosphate + phosphate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Neisseria gonorrhoeae | - |
- |
- |
Neisseria meningitidis | - |
- |
- |
Salmonella enterica subsp. enterica serovar Typhi | - |
- |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Vibrio cholerae serotype O1 | - |
- |
- |
Yersinia pestis | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O | reaction mechanism, active site structure, substrate and product binding structures, structure-function relationship | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | - |
Neisseria gonorrhoeae | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | - |
Neisseria meningitidis | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | - |
Yersinia pestis | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | - |
Salmonella enterica subsp. enterica serovar Typhi | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | - |
Vibrio cholerae serotype O1 | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | involved in the de novo synthesis of vitamin B6 | Salmonella enterica subsp. enterica serovar Typhimurium | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | involved in the de novo synthesis of vitamin B6 | Neisseria gonorrhoeae | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | involved in the de novo synthesis of vitamin B6 | Neisseria meningitidis | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | involved in the de novo synthesis of vitamin B6 | Yersinia pestis | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | involved in the de novo synthesis of vitamin B6 | Salmonella enterica subsp. enterica serovar Typhi | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | involved in the de novo synthesis of vitamin B6 | Vibrio cholerae serotype O1 | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | key enzyme in the group of pdx gene-encoded enzymes involved in the de novo synthesis of vitamin B6 | Escherichia coli | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | multistep ring closure reaction, the phosphate group of the substrate is required for activity | Escherichia coli | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
additional information | 1-deoxy-D-xylulose is no substrate | Escherichia coli | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | enzyme structure, the monomer comprises a single domain which folds as a (beta/alpha)8 barrel or TIM barrel, 3 extra helices complete the scaffold mediating the intersubunit contact | Escherichia coli |
octamer | in solution, crystal structure | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
PdxJ | - |
Escherichia coli |
PNP synthase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
PNP synthase | - |
Escherichia coli |
PNP synthase | - |
Neisseria gonorrhoeae |
PNP synthase | - |
Neisseria meningitidis |
PNP synthase | - |
Yersinia pestis |
PNP synthase | - |
Salmonella enterica subsp. enterica serovar Typhi |
PNP synthase | - |
Vibrio cholerae serotype O1 |